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Mbtd1
Gene Detail
Symbol

Name
ID
Mbtd1
mbt domain containing 1
MGI:2143977
Synonyms
hemp
Feature Type
protein coding gene
Genetic Map
Chromosome 11
58.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:93885852-93946985 bp, + strand
From VEGA annotation of GRCm38

  61134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41185  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mbtd1

Human
homologs
Human Homolog MBTD1, mbt domain containing 1
NCBI Gene ID 54799
neXtProt AC  NX_Q05BQ5
Human Synonyms  SA49P01
Human Chr (Location)  17q21.33; chr17:51177425-51260427 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(61) : Gene trapped(56) Targeted(5)
Genomic Mutations involving Mbtd1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality and severe abnormalities in hematopoietic stem cell function and skeletal formation.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Mbtd1 interacts with 427 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process chromatin modification, embryonic skeletal system development, ...
Component nucleus
Function metal ion binding, zinc ion binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (23)    Tissues (17)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
RT-PCR 8
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000001464 (Evidence)
Ensembl Gene ModelENSMUSG00000059474 (Evidence)
Entrez Gene103537 (Evidence)
DFCITC1575608, TC1595813, TC1647321, TC1669419, TC1677493
DoTSDT.101155249, DT.101229132, DT.101340529, DT.110548120, DT.110548148, DT.94358668
NIA Mouse Gene IndexU013196
Consensus CDS ProjectCCDS48883.1
International Mouse Knockout Project StatusMbtd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001464 VEGA Gene Model | MGI Sequence Detail 61134 C57BL/6J ±  kb
transcript OTTMUST00000002879 VEGA | MGI Sequence Detail 5232 Not Applicable 
polypeptide OTTMUSP00000001406 VEGA | MGI Sequence Detail 631 Not Applicable 

For the selected sequences
All sequences(143) RefSeq(60) UniProt(8)
Polymorphisms
SNPs within 2kb(478 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004092 Mbt repeat
InterPro IPR012313 Zinc finger, FCS-type
Protein Ontology PR:000029622 MBT domain-containing protein 1
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)
Other
accession IDs
MGI:2144082

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory