Mgat4b MGI Mouse Gene Detail - MGI:2143974 - mannoside acetylglucosaminyltransferase 4, isoenzyme B

Mgat4b Gene Detail

Symbol

Mgat4b
Name

mannoside acetylglucosaminyltransferase 4, isoenzyme B

Feature Type

protein coding gene
IDs

MGI:2143974
NCBI Gene: 103534
Gene Overview

MyGene.info: MGAT4B

Sequence Map

Chr11:50210890-50235103 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

24214 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 30.37 cM
Mapping Data

1 experiment

Human Ortholog

MGAT4B, mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B

Vertebrate Orthologs

10

Human Ortholog

MGAT4B, mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
Orthology source: HomoloGene, HGNC
Synonyms

GNT-IV, GNT-IVB
Links

HGNC:7048

NCBI Gene ID: 11282

neXtProt AC: NX_Q9UQ53

UniProt: Q9UQ53
Chr Location

5q35.3; chr5:179797597-179806952 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8611
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: MGAT4B
Gene Tree

Mgat4b

less

Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Gene trapped

18
Targeted

2
Genomic Mutations

1 involving Mgat4b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available

Mice homozygous for a floxed targeted allele are viable and do not display any gross physical or behavioral abnormalities.

less

All GO Annotations

12
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

130
Tissues

100
cDNA Data

71
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mgat4b

less

Mgat4b interacts with 165 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

less

All Sequences

61
RefSeq

2
UniProt

3
CCDS

CCDS24630.1
UniGene

86759

			Length	Strain/Species	Flank
genomic	OTTMUSG00000005573	VEGA Gene Model \| MGI Sequence Detail	24214	C57BL/6J	± kb
transcript	OTTMUST00000012384	VEGA \| MGI Sequence Detail	2429	Not Applicable
polypeptide	OTTMUSP00000005734	VEGA \| MGI Sequence Detail	548	Not Applicable

less

SNPs within 2kb

63 from dbSNP Build 142

less

UniProt

3 Sequences
Protein Ontology

PR:000010382 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

(term hierarchy)
EC

2.4.1.145
InterPro Domains

IPR006759 Glycosyl transferase family 54

less

All nucleic 71

cDNA 71

Microarray probesets 2

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 8
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:217242 Kurimoto A, et al., The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. J Biol Chem. 2014 Apr 25;289(17):11704-14

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/15/2017 MGI 6.10