Mgat4b MGI Mouse Gene Detail - MGI:2143974 - mannoside acetylglucosaminyltransferase 4, isoenzyme B

Symbol

Mgat4b
Name

mannoside acetylglucosaminyltransferase 4, isoenzyme B

Feature Type

protein coding gene
IDs

MGI:2143974
NCBI Gene: 103534
Gene Overview

MyGene.info: MGAT4B
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:50225335-50235103 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 30.37 cM
Mapping Data

1 experiment

SNPs within 2kb

31 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2143974	protein coding gene	Chr11:50210890-50235103 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0018244	protein coding gene	Chr11:49377256-49403714 (+)
A/J	MGP_AJ_G0018212	protein coding gene	Chr11:47483286-47507642 (+)
AKR/J	MGP_AKRJ_G0018182	protein coding gene	Chr11:48994312-49019533 (+)
BALB/cJ	MGP_BALBcJ_G0018182	protein coding gene	Chr11:47762632-47787006 (+)
C3H/HeJ	MGP_C3HHeJ_G0017995	protein coding gene	Chr11:49000695-49025717 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018633	protein coding gene	Chr11:50839386-50866525 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016285	protein coding gene	Chr11:45102602-45127573 (+)
CAST/EiJ	MGP_CASTEiJ_G0017557	protein coding gene	Chr11:48969897-48997730 (+)
CBA/J	MGP_CBAJ_G0017970	protein coding gene	Chr11:53199959-53224042 (+)
DBA/2J	MGP_DBA2J_G0018077	protein coding gene	Chr11:47282689-47306926 (+)
FVB/NJ	MGP_FVBNJ_G0018071	protein coding gene	Chr11:46907553-46933287 (+)
LP/J	MGP_LPJ_G0018152	protein coding gene	Chr11:49710648-49738621 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018096	protein coding gene	Chr11:54725997-54753954 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018677	protein coding gene	Chr11:49101119-49128865 (+)
PWK/PhJ	MGP_PWKPhJ_G0017335	protein coding gene	Chr11:47682719-47711028 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017130	protein coding gene	Chr11:48796421-48820443 (+)
WSB/EiJ	MGP_WSBEiJ_G0017610	protein coding gene	Chr11:48740497-48766380 (+)

Human Ortholog

MGAT4B, alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

Vertebrate Orthologs

10

Human Ortholog

MGAT4B, alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
Orthology source: HomoloGene, HGNC
Synonyms

GNT-IV, GNT-IVB
Links

HGNC:7048

NCBI Gene ID: 11282

neXtProt AC: NX_Q9UQ53

UniProt: Q9UQ53
Chr Location

5q35.3; chr5:179797597-179806952 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8611
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: MGAT4B
Gene Tree

Mgat4b

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

5
Targeted

2
Genomic Mutations

1 involving Mgat4b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a floxed targeted allele are viable and do not display any gross physical or behavioral abnormalities.

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All GO Annotations

9
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

130
Tissues

100
cDNA Data

71
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mgat4b

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Mgat4b interacts with 165 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

69
RefSeq

2
UniProt

3
CCDS

CCDS24630.1
UniGene

86759

Ensembl

ENSMUSG00000036620 (Evidence)
NCBI Gene

103534

			Length	Strain/Species	Flank
genomic	103534	NCBI Gene Model \| MGI Sequence Detail	9769	C57BL/6J	± kb
transcript	NM_145926	RefSeq \| MGI Sequence Detail	2429	C57BL/6
polypeptide	Q812F8	UniProt \| EBI \| MGI Sequence Detail	548	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010382 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

(term hierarchy)
EC

2.4.1.145
InterPro Domains

IPR006759 Glycosyl transferase family 54

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All nucleic 71

cDNA 71

Microarray probesets 2

Summaries

All 27

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 7
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:217242 Kurimoto A, et al., The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. J Biol Chem. 2014 Apr 25;289(17):11704-14

TSS for Mgat4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101228	Chr11:50210944-50210958 (+)	-14,384 bp
Tssr101231	Chr11:50225068-50225087 (+)	-257 bp
Tssr101232	Chr11:50225308-50225311 (+)	-25 bp
Tssr101233	Chr11:50225315-50225429 (+)	37 bp
Tssr101234	Chr11:50225475-50225492 (+)	149 bp
Tssr101236	Chr11:50232051-50232076 (+)	6,729 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/08/2019 MGI 6.13