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Mgat4b Gene Detail
Summary
  • Symbol
    Mgat4b
  • Name
    mannoside acetylglucosaminyltransferase 4, isoenzyme B
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143974
    NCBI Gene: 103534
  • Gene Overview
    MyGene.info: MGAT4B
Location & Maps
more
  • Sequence Map
    Chr11:50210890-50235103 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      24214 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 30.37 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MGAT4B, mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MGAT4B, mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GNT-IV, GNT-IVB
  • Links
    NCBI Gene ID: 11282
    neXtProt AC: NX_Q9UQ53

  • Chr Location
    5q35; chr5:179797597-179806952 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 8611
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MGAT4B
  • Gene Tree
    Mgat4b
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    18
  • Targeted
    2
  • Genomic Mutations
    1 involving Mgat4b
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Mice homozygous for a floxed targeted allele are viable and do not display any gross physical or behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    130
  • Tissues
    100
  • cDNA Data
    71
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005573 VEGA Gene Model | MGI Sequence Detail 24214 C57BL/6J ±  kb
transcript OTTMUST00000012384 VEGA | MGI Sequence Detail 2429 Not Applicable  
polypeptide OTTMUSP00000005734 VEGA | MGI Sequence Detail 548 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    63 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010382 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
  • EC
    2.4.1.145
  • InterPro Domains
    IPR006759 Glycosyl transferase family 54
Molecular
Reagents
less
  • All nucleic 71
    cDNA 71

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:217242 Kurimoto A, et al., The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. J Biol Chem. 2014 Apr 25;289(17):11704-14
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory