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Enpp3 Gene Detail
Summary
  • Symbol
    Enpp3
  • Name
    ectonucleotide pyrophosphatase/phosphodiesterase 3
  • Synonyms
    CD203c, MGC:6548
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143702
    NCBI Gene: 209558
  • Gene Overview
    MyGene.info: ENPP3
Location & Maps
more
  • Sequence Map
    Chr10:24773814-24836195 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62382 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ENPP3, ectonucleotide pyrophosphatase/phosphodiesterase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ENPP3, ectonucleotide pyrophosphatase/phosphodiesterase 3
    Orthology source: HomoloGene
  • Synonyms
    B10, CD203c, NPP3, PD-IBETA, PDNP3
  • Links
    NCBI Gene ID: 5169
    neXtProt AC: NX_O14638

  • Chr Location
    6q22; chr6:131637235-131747413 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Chemically induced (other)
    1
  • Gene trapped
    43
  • Targeted
    3
  • Genomic Mutations
    1 involving Enpp3
  • Incidental Mutations
Mice homozygous for a knockout allele exhibit increased numbers of basophils and mast cells with increased susceptibility to chronic allergic responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 209558 NCBI Gene Model | MGI Sequence Detail 62382 C57BL/6J ±  kb
transcript NM_134005 RefSeq | MGI Sequence Detail 2815 C57BL/6  
polypeptide Q6DYE8 UniProt | EBI | MGI Sequence Detail 874 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    555 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000001344 ectonucleotide pyrophosphatase/phosphodiesterase family member 3
  • EC
  • InterPro Domains
    IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
    IPR017850 Alkaline-phosphatase-like, core domain
    IPR001604 DNA/RNA non-specific endonuclease
    IPR024873 Ectonucleotide pyrophosphatase/phosphodiesterase family
    IPR029885 Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
    IPR020821 Extracellular Endonuclease, subunit A
    IPR001212 Somatomedin B domain
    IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
Molecular
Reagents
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  • All nucleic 70
    cDNA 69
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:223825 Tsai SH, et al., The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity. 2015 Feb 17;42(2):279-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory