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Upb1
Gene Detail
Symbol

Name
ID
Upb1
ureidopropionase, beta
MGI:2143535
Feature Type
protein coding gene
Genetic Map
Chromosome 10
38.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:75406911-75441679 bp, + strand
From VEGA annotation of GRCm38

  34769 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9471  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UPB1
Protein SuperFamily: nitrilase (carbon-nitrogen hydrolase)
Gene Tree: Upb1

Human
homologs
UPB1, ureidopropionase, beta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51733
neXtProt AC: NX_Q9UBR1

Human Synonyms: BUP1

Human Chr (Location): 22q11.2; chr22:24494467-24528390 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human UPB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Upb1 interacts with 198 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process beta-alanine metabolic process, liver development, ...
Component cytoplasm, extracellular exosome
Function beta-ureidopropionase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(59)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase upb1    NEW 
Molecular
reagents
All nucleic(59) cDNA(59)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031799 (Evidence)
Ensembl Gene Model ENSMUSG00000033427 (Evidence)
Entrez Gene 103149 (Evidence)
UniGene 441195
DFCI TC1580721
DoTS DT.530122, DT.91356976, DT.97402365
NIA Mouse Gene Index U011658
EC 3.5.1.6
Consensus CDS Project CCDS23925.1
International Mouse Phenotyping Consortium Status Upb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031799 VEGA Gene Model | MGI Sequence Detail 34769 C57BL/6J ±  kb
transcript OTTMUST00000078814 VEGA | MGI Sequence Detail 3042 Not Applicable 
polypeptide OTTMUSP00000041948 VEGA | MGI Sequence Detail 393 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(182 from dbSNP Build 137)    SNPs within 2kb including multiple locations(188)
Protein-related
information
ResourceIDDescription
InterPro IPR003010 Carbon-nitrogen hydrolase
Protein Ontology PR:000017107 beta-ureidopropionase
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory