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Rdh9
Gene Detail
 Symbol
Name
ID
Rdh9
retinol dehydrogenase 9
MGI:2143528
Synonyms Crad3
Feature Type protein coding gene
Genetic Map
Chromosome 10
75.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:127776386-127792697 bp, + strand
From VEGA annotation of GRCm38

  16312 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129514  Vertebrate Homology Class
1 human; 5 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 8 western clawed frog; 1 zebrafish

Protein SuperFamily: retinol dehydrogenase
Gene Tree: Rdh9

Human
homologs
Human Homolog RDH16, retinol dehydrogenase 16 (all-trans)
NCBI Gene ID 8608
neXtProt AC  NX_O75452
Human Synonyms  RODH-4, SDR9C8
Human Chr (Location)  12q13.3; chr12:56951431-56959374 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable, fertile and healthy, with no apparent alterations in tissue retinoid and serum dihydrotestosterone levels.
 
Interactions
Rdh9 interacts with 195 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process 9-cis-retinoic acid biosynthetic process, oxidation-reduction process
Component cellular_component
Function retinol dehydrogenase activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027659 (Evidence)
Ensembl Gene ModelENSMUSG00000056148 (Evidence)
Entrez Gene103142 (Evidence)
UniGene235814
DFCITC1588203, TC1596822
DoTSDT.110592362, DT.87060812, DT.94338687
NIA Mouse Gene IndexU012163
Consensus CDS ProjectCCDS24251.1
International Mouse Knockout Project StatusRdh9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027659 VEGA Gene Model | MGI Sequence Detail 16312 C57BL/6J ±  kb
transcript OTTMUST00000068438 VEGA | MGI Sequence Detail 2698 Not Applicable 
polypeptide OTTMUSP00000034607 VEGA | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(62 from dbSNP Build 137)    SNPs within 2kb including multiple locations(64)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
References (Earliest) J:83534 Zhuang R, et al., cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a short-chain dehydrogenase active in a reconstituted path of 9-cis-retinoic acid biosynthesis in intact cells. Biochemistry. 2002 Mar 12;41(10):3477-83
(Latest) J:177585 Hesse K, et al., AP-2delta is a crucial transcriptional regulator of the posterior midbrain. PLoS One. 2011;6(8):e23483
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory