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Slc6a15 Gene Detail
Summary
  • Symbol
    Slc6a15
  • Name
    solute carrier family 6 (neurotransmitter transporter), member 15
  • Synonyms
    v7-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143484
    NCBI Gene: 103098
  • Gene Overview
    MyGene.info: SLC6A15
Location & Maps
more
  • Sequence Map
    Chr10:103367808-103419378 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51571 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 53.98 cM, cytoband D1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLC6A15, solute carrier family 6 member 15
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC6A15, solute carrier family 6 member 15
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hv7-3, NTT73, SBAT1, V7-3
  • Links
    NCBI Gene ID: 55117
    neXtProt AC: NX_Q9H2J7

  • Chr Location
    12q21.3; chr12:84859488-84913615 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    4
  • Genomic Mutations
    1 involving Slc6a15
  • Incidental Mutations
Mice homozygous for a null allele exhibit decreased synaptosome transport activities but exhibit no behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019894 Ensembl Gene Model | MGI Sequence Detail 51571 C57BL/6J ±  kb
transcript ENSMUST00000074204 Ensembl | MGI Sequence Detail 3643 Not Applicable  
polypeptide ENSMUSP00000073829 Ensembl | MGI Sequence Detail 729 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    457 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015181 sodium-dependent neutral amino acid transporter B(0)AT2
  • InterPro Domains
    IPR000175 Sodium:neurotransmitter symporter
    IPR002438 Sodium:neurotransmitter symporter, orphan
Molecular
Reagents
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  • All nucleic 41
    cDNA 40
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGI:2143583, MGI:2143584
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:206404 Drgonova J, et al., Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes. PLoS One. 2013;8(9):e68245

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory