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Il20rb Gene Detail
Summary
  • Symbol
    Il20rb
  • Name
    interleukin 20 receptor beta
  • Synonyms
    Fndc6, Il20R2, LOC213208
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143266
    NCBI Gene: 213208
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:100457719-100486473 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 52.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    421 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143266
protein coding gene Chr9:100457719-100486788 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035176
protein coding gene Chr9:101893489-101927838 (-)
A/J MGP_AJ_G0035157
protein coding gene Chr9:98297834-98327734 (-)
AKR/J MGP_AKRJ_G0035089
protein coding gene Chr9:100698713-100730446 (-)
BALB/cJ MGP_BALBcJ_G0035150
protein coding gene Chr9:97980059-98009197 (-)
C3H/HeJ MGP_C3HHeJ_G0034860
protein coding gene Chr9:101117919-101149897 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035670
protein coding gene Chr9:104815873-104844575 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032569
protein coding gene Chr9:95946433-95974371 (-)
CAST/EiJ MGP_CASTEiJ_G0034171
protein coding gene Chr9:100900723-100932281 (-)
CBA/J MGP_CBAJ_G0034828
protein coding gene Chr9:108435791-108469785 (-)
DBA/2J MGP_DBA2J_G0034990
protein coding gene Chr9:97781499-97810569 (-)
FVB/NJ MGP_FVBNJ_G0034938
protein coding gene Chr9:96594791-96623765 (-)
LP/J MGP_LPJ_G0035066
protein coding gene Chr9:102122574-102155760 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034977
protein coding gene Chr9:110315948-110346925 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035692
protein coding gene Chr9:100950073-100980009 (-)
PWK/PhJ MGP_PWKPhJ_G0033878
protein coding gene Chr9:98005988-98035208 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033714
protein coding gene Chr9:101004454-101032950 (-)
WSB/EiJ MGP_WSBEiJ_G0034291
protein coding gene Chr9:100811217-100843753 (-)



Homology
more
  • Human Ortholog
    IL20RB, interleukin 20 receptor subunit beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IL20RB, interleukin 20 receptor subunit beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DIRS1, FNDC6, IL-20R2
  • Links
    NCBI Gene ID: 53833
    neXtProt AC: NX_Q6UXL0
    UniProt: Q6UXL0

  • Chr Location
    3q22.3; chr3:136957865-137011085 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 4 alleles in 5 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display enhanced antigen-specific T cell responses. Mice homozygous for a reporter allele fail to exhibit epidermal hyperplasia in an interleukin-23 (IL-23)-dependent psoriasis mouse model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 213208 NCBI Gene Model | MGI Sequence Detail 28755 C57BL/6J ±  kb
transcript NM_001033543 RefSeq | MGI Sequence Detail 2479 C57BL/6  
polypeptide NP_001028715 RefSeq | MGI Sequence Detail 308 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR013783 Immunoglobulin-like fold
    IPR015373 Interferon/interleukin receptor domain
Molecular
Reagents
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  • All nucleic 33
    Genomic 1
    cDNA 32

    Microarray probesets 5
Other
Accession IDs
less
MGI:2685032
References
more
  • Summaries
    All 37
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:124591 Chan JR, et al., IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med. 2006 Nov 27;203(12):2577-87
  • Latest
    J:252471 Zhou H, et al., Alternative splicing directs two IL-20R2 isoforms and is responsible for the incomplete gene knockout via the exon I ablation. Genes Immun. 2016 Jun;17(4):220-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory