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Il20rb Gene Detail
Summary
  • Symbol
    Il20rb
  • Name
    interleukin 20 receptor beta
  • Synonyms
    Fndc6, Il20R2, LOC213208
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143266
    NCBI Gene: 213208
Location & Maps
more
  • Sequence Map
    Chr9:100457719-100486788 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29070 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 52.66 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IL20RB, interleukin 20 receptor subunit beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IL20RB, interleukin 20 receptor subunit beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DIRS1, FNDC6, IL-20R2
  • Links
    NCBI Gene ID: 53833
    neXtProt AC: NX_Q6UXL0

  • Chr Location
    3q22.3; chr3:136957865-137011085 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Il20rb
  • Incidental Mutations
Mice homozygous for a knock-out allele display enhanced antigen-specific T cell responses. Mice homozygous for a reporter allele fail to exhibit epidermal hyperplasia in an interleukin-23 (IL-23)-dependent psoriasis mouse model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027484 VEGA Gene Model | MGI Sequence Detail 29070 C57BL/6J ±  kb
transcript OTTMUST00000068017 VEGA | MGI Sequence Detail 2793 Not Applicable  
polypeptide OTTMUSP00000034310 VEGA | MGI Sequence Detail 308 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    423 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR015373 Interferon/interleukin receptor domain
Molecular
Reagents
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  • All nucleic 32
    cDNA 32

    Microarray probesets 5
Other
Accession IDs
less
MGI:2685032
References
more
  • Summaries
    All 30
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:124591 Chan JR, et al., IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med. 2006 Nov 27;203(12):2577-87
  • Latest
    J:205442 Myles IA, et al., Signaling via the IL-20 receptor inhibits cutaneous production of IL-1beta and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus. Nat Immunol. 2013 Aug;14(8):804-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory