Phldb1 MGI Mouse Gene Detail - MGI:2143230 - pleckstrin homology like domain, family B, member 1

Symbol

Phldb1
Name

pleckstrin homology like domain, family B, member 1
Synonyms

D330037A14Rik, LL5A, mKIAA0638

Feature Type

protein coding gene
IDs

MGI:2143230
NCBI Gene: 102693
Gene Overview

MyGene.info: PHLDB1
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:44597601-44646495 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM
Mapping Data

3 experiments

SNPs within 2kb

449 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2143230	protein coding gene	Chr9:44597601-44649800 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034716	protein coding gene	Chr9:43210411-43259188 (-)
A/J	MGP_AJ_G0034697	protein coding gene	Chr9:41989775-42040997 (-)
AKR/J	MGP_AKRJ_G0034624	protein coding gene	Chr9:42863796-42912960 (-)
BALB/cJ	MGP_BALBcJ_G0034688	protein coding gene	Chr9:41736289-41785146 (-)
C3H/HeJ	MGP_C3HHeJ_G0034399	protein coding gene	Chr9:43316947-43366819 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035209	protein coding gene	Chr9:44485055-44537513 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032124	protein coding gene	Chr9:41560917-41610583 (-)
CAST/EiJ	MGP_CASTEiJ_G0033721	protein coding gene	Chr9:43178878-43228502 (-)
CBA/J	MGP_CBAJ_G0034371	protein coding gene	Chr9:46107267-46158777 (-)
DBA/2J	MGP_DBA2J_G0034530	protein coding gene	Chr9:41893596-41942479 (-)
FVB/NJ	MGP_FVBNJ_G0034471	protein coding gene	Chr9:41153718-41204172 (-)
LP/J	MGP_LPJ_G0034611	protein coding gene	Chr9:43506809-43557026 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034515	protein coding gene	Chr9:47941254-47991154 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035230	protein coding gene	Chr9:42780677-42830331 (-)
PWK/PhJ	MGP_PWKPhJ_G0033426	protein coding gene	Chr9:41778233-41827321 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033262	protein coding gene	Chr9:43088154-43136882 (-)
WSB/EiJ	MGP_WSBEiJ_G0033834	protein coding gene	Chr9:42807507-42859125 (-)

Human Ortholog

PHLDB1, pleckstrin homology like domain family B member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PHLDB1, pleckstrin homology like domain family B member 1
Synonyms

LL5A
Links

HGNC:23697

NCBI Gene ID: 23187

neXtProt AC: NX_Q86UU1

UniProt: Q86UU1
Chr Location

11q23.3; chr11:118606296-118658038 (+) GRCh38.p7

Alliance of Genome Resources

Phldb1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PHLDB1
Gene Tree

Phldb1

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Gene trapped

7
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

94
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase phldb1

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Phldb1 interacts with 207 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

188
RefSeq

100
UniProt

17
CCDS

CCDS23118.1

Ensembl

ENSMUSG00000048537 (Evidence)
NCBI Gene

102693

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048537	Ensembl Gene Model \| MGI Sequence Detail	48895	C57BL/6J	± kb
transcript	ENSMUST00000138356	Ensembl \| MGI Sequence Detail	5600	Not Applicable
polypeptide	ENSMUSP00000120208	Ensembl \| MGI Sequence Detail	1449	Not Applicable

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UniProt

17 Sequences
Protein Ontology

PR:000030919 pleckstrin homology-like domain family B member 1

(term hierarchy)
InterPro Domains

IPR000253 Forkhead-associated (FHA) domain

IPR037810 PHLDB1/2/3, PH domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR008984 SMAD/FHA domain superfamily

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All nucleic 94

cDNA 94

Microarray probesets 4

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 7
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Phldb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr89196	Chr9:44646513-44646537 (-)	-30 bp
Tssr89195	Chr9:44646486-44646510 (-)	-3 bp
Tssr89194	Chr9:44646481-44646484 (-)	12 bp
Tssr89193	Chr9:44645497-44645508 (-)	992 bp
Tssr89192	Chr9:44645309-44645321 (-)	1,180 bp
Tssr89191	Chr9:44632680-44632781 (-)	13,764 bp
Tssr89190	Chr9:44632586-44632638 (-)	13,883 bp
Tssr89189	Chr9:44630072-44630075 (-)	16,421 bp
Tssr89188	Chr9:44624493-44624515 (-)	21,991 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/15/2021 MGI 6.17