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Mapkapk3 Gene Detail
Summary
  • Symbol
    Mapkapk3
  • Name
    mitogen-activated protein kinase-activated protein kinase 3
  • Synonyms
    MK3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143163
    NCBI Gene: 102626
  • Gene Overview
    MyGene.info: MAPKAPK3
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107254927-107289877 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 57.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143163
protein coding gene Chr9:107254926-107289877 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035248
protein coding gene Chr9:109111335-109146256 (-)
A/J MGP_AJ_G0035227
protein coding gene Chr9:105149671-105185525 (-)
AKR/J MGP_AKRJ_G0035159
protein coding gene Chr9:107769645-107808850 (-)
BALB/cJ MGP_BALBcJ_G0035221
protein coding gene Chr9:104818826-104854723 (-)
C3H/HeJ MGP_C3HHeJ_G0034931
protein coding gene Chr9:108168412-108206378 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035741
protein coding gene Chr9:112106568-112147552 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032639
protein coding gene Chr9:102578926-102614319 (-)
CAST/EiJ MGP_CASTEiJ_G0034242
protein coding gene Chr9:108094983-108136497 (-)
CBA/J MGP_CBAJ_G0034899
protein coding gene Chr9:116084784-116119742 (-)
DBA/2J MGP_DBA2J_G0035060
protein coding gene Chr9:104602205-104644551 (-)
FVB/NJ MGP_FVBNJ_G0035008
protein coding gene Chr9:103362091-103396711 (-)
LP/J MGP_LPJ_G0035136
protein coding gene Chr9:109317605-109354391 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035047
protein coding gene Chr9:117670269-117708930 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035762
protein coding gene Chr9:108036781-108073004 (-)
PWK/PhJ MGP_PWKPhJ_G0033949
protein coding gene Chr9:104914551-104951113 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033784
protein coding gene Chr9:108097937-108138889 (-)
WSB/EiJ MGP_WSBEiJ_G0034363
protein coding gene Chr9:107923384-107960696 (-)



Homology
more
  • Human Ortholog
    MAPKAPK3, mitogen-activated protein kinase-activated protein kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPKAPK3, mitogen-activated protein kinase-activated protein kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    3PK, MAPKAP3, MAPKAP-K3, MAPKAPK-3, MDPT3, MK-3
  • Links
    NCBI Gene ID: 7867
    neXtProt AC: NX_Q16644
    UniProt: Q16644

  • Chr Location
    3p21.2; chr3:50611862-50649297 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MAPKAPK3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    16 phenotype references
Mice homozygous for a knock-out allele are viable and fertile and display normal tissue morphology, behavior, and LPS-induced production of cytokines. Eyes of homozygous null mice show defects in Bruch's membrane, with disorganized architecture and variability in thickness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032577 Ensembl Gene Model | MGI Sequence Detail 34951 C57BL/6J ±  kb
transcript ENSMUST00000035194 Ensembl | MGI Sequence Detail 2816 Not Applicable  
polypeptide ENSMUSP00000035194 Ensembl | MGI Sequence Detail 384 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 11
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:240712 Hayakawa M, et al., Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem. 2017 Feb 03;292(5):1762-1772

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory