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Mapkapk3
Gene Detail
Symbol

Name
ID
Mapkapk3
mitogen-activated protein kinase-activated protein kinase 3
MGI:2143163
Synonyms
MK3
Feature Type
protein coding gene
Genetic Map
Chromosome 9
57.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:107254927-107289877 bp, - strand
From VEGA annotation of GRCm38

  34951 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55836  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAPKAPK3
Protein SuperFamily: MAP kinase-activated protein kinase 2/3
Gene Tree: Mapkapk3

Human
homologs
MAPKAPK3, mitogen-activated protein kinase-activated protein kinase 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7867
neXtProt AC: NX_Q16644

Human Synonyms: 3PK, MAPKAP3, MAPKAP-K3, MAPKAPK-3, MK-3

Human Chr (Location): 3p21.3; chr3:50611862-50649297 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(13) Targeted(3)
Incidental mutations (data from CvDC )
 
Mice homozygous for a knock-out allele are viable and fertile and display normal tissue morphology, behavior, and LPS-induced production of cytokines.
 
Interactions
Mapkapk3 interacts with 175 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cell surface receptor signaling pathway, macropinocytosis, ...
Component cytoplasm, nuclear membrane, ...
Function ATP binding, calcium-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (251)    Tissues (35)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 251
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mapkapk3    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000030250 (Evidence)
Ensembl Gene Model ENSMUSG00000032577 (Evidence)
Entrez Gene 102626 (Evidence)
DFCI TC1589278, TC1717820, TC1575513
DoTS DT.101226743, DT.101179306, DT.87027199, DT.99844374
NIA Mouse Gene Index U031313
EC 2.7.11.1
Consensus CDS Project CCDS23487.1
International Mouse Phenotyping Consortium Status Mapkapk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030250 VEGA Gene Model | MGI Sequence Detail 34951 C57BL/6J ±  kb
transcript OTTMUST00000074887 VEGA | MGI Sequence Detail 2816 Not Applicable 
polypeptide OTTMUSP00000039153 VEGA | MGI Sequence Detail 384 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(10) UniProt(4)
Polymorphisms
SNPs within 2kb(472 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027442 MAP kinase activated protein kinase, C-terminal domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010166 MAP kinase-activated protein kinase 3
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:217839 Kother K, et al., MAPKAP kinase 3 suppresses Ifng gene expression and attenuates NK cell cytotoxicity and Th1 CD4 T-cell development upon influenza A virus infection. FASEB J. 2014 Oct;28(10):4235-46
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory