Mapkapk3
Gene Detail

Symbol Name ID

Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 MGI:2143163

Synonyms

MK3

Feature Type

protein coding gene

Genetic Map

Chromosome 9

57.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:107254927-107289877 bp, - strand From VEGA annotation of GRCm38   34951 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55836  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: MAP kinase-activated protein kinase 2/3
Gene Tree: Mapkapk3

Human homologs

Human Homolog		MAPKAPK3, mitogen-activated protein kinase-activated protein kinase 3
NCBI Gene ID		7867
neXtProt AC		NX_Q16644
Human Synonyms		3PK, MAPKAP3, MAPKAP-K3, MAPKAPK-3, MK-3
Human Chr (Location)		3p21.3; chr3:50649293-50686728 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(16) : Targeted(3) Gene trapped(13)
 

Mice homozygous for a knock-out allele are viable and fertile and display normal tissue morphology, behavior, and LPS-induced production of cytokines.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	macropinocytosis, peptidyl-serine phosphorylation, ...
Component	cytoplasm, nucleus
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (251)    Tissues (35)    Images (50)
Theiler Stages: 23

Assay Type	Results
RNA in situ	251

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(10)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030250 (Evidence)
Ensembl Gene Model	ENSMUSG00000032577 (Evidence)
Entrez Gene	102626 (Evidence)
DFCI	TC1575513, TC1589278, TC1717820
DoTS	DT.101179306, DT.101226743, DT.87027199, DT.99844374
NIA Mouse Gene Index	U031313
EC	2.7.11.1
Consensus CDS Project	CCDS23487.1
International Mouse Knockout Project Status	Mapkapk3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030250	VEGA Gene Model | MGI Sequence Detail	34951	C57BL/6J
transcript	OTTMUST00000074887	VEGA | MGI Sequence Detail	2816	Not Applicable
polypeptide	OTTMUSP00000039153	VEGA | MGI Sequence Detail	384	Not Applicable

All sequences(53) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(337 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010166	MAP kinase-activated protein kinase 3

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)