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Mapkapk3
Gene Detail
 Symbol
Name
ID
Mapkapk3
mitogen-activated protein kinase-activated protein kinase 3
MGI:2143163
Synonyms MK3
Feature Type protein coding gene
Genetic Map
Chromosome 9
57.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:107254927-107289877 bp, - strand
From VEGA annotation of GRCm38

  34951 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55836  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: MAP kinase-activated protein kinase 2/3
Gene Tree: Mapkapk3

Human
homologs
Human Homolog MAPKAPK3, mitogen-activated protein kinase-activated protein kinase 3
NCBI Gene ID 7867
neXtProt AC  NX_Q16644
Human Synonyms  3PK, MAPKAP3, MAPKAP-K3, MAPKAPK-3, MK-3
Human Chr (Location)  3p21.3; chr3:50611862-50649297 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(13) Targeted(3)
 
Mice homozygous for a knock-out allele are viable and fertile and display normal tissue morphology, behavior, and LPS-induced production of cytokines.
 
Interactions
Mapkapk3 interacts with 175 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process macropinocytosis, peptidyl-serine phosphorylation, ...
Component cytoplasm, nuclear membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (251)    Tissues (35)    Images (50)
Theiler Stages: 23
Assay TypeResults
RNA in situ 251
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030250 (Evidence)
Ensembl Gene ModelENSMUSG00000032577 (Evidence)
Entrez Gene102626 (Evidence)
DFCITC1575513, TC1589278, TC1717820
DoTSDT.101179306, DT.101226743, DT.87027199, DT.99844374
NIA Mouse Gene IndexU031313
EC2.7.11.1
Consensus CDS ProjectCCDS23487.1
International Mouse Knockout Project StatusMapkapk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030250 VEGA Gene Model | MGI Sequence Detail 34951 C57BL/6J ±  kb
transcript OTTMUST00000074887 VEGA | MGI Sequence Detail 2816 Not Applicable 
polypeptide OTTMUSP00000039153 VEGA | MGI Sequence Detail 384 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(10) UniProt(4)
Polymorphisms SNPs within 2kb(472 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027442 MAP kinase activated protein kinase, C-terminal domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010166 MAP kinase-activated protein kinase 3
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:204489 Scharf M, et al., Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function. Mol Cell Biol. 2013 Jul;33(13):2586-602
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory