Ano10 MGI Mouse Gene Detail - MGI:2143103

Symbol

Ano10
Name

anoctamin 10
Synonyms

Tmem16k

Feature Type

protein coding gene
IDs

MGI:2143103
NCBI Gene: 102566
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:122004958-122123440 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 72.94 cM
Mapping Data

1 experiment

SNPs within 2kb

3316 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2143103	protein coding gene	Chr9:122004940-122123489 (-)
129S1/SvImJ	ENSMUSG00200029196	protein coding gene	Chr9:119129595-119229389 (-)
A/J	ENSMUSG00195026983	protein coding gene	Chr9:118292604-118393880 (-)
AKR/J	ENSMUSG00220019144	protein coding gene	Chr9:118746355-118846114 (-)
BALB/cJ	ENSMUSG00180027918	protein coding gene	Chr9:118830606-118931892 (-)
C3H/HeJ	ENSMUSG00175018741	protein coding gene	Chr9:119068850-119170117 (-)
C57BL/6NJ	ENSMUSG00215029517	protein coding gene	Chr9:118959613-119059399 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032841	protein coding gene	Chr9:117543087-117661787 (-)
CAST/EiJ	ENSTCUG00005016464	protein coding gene	Chr9:118673643-118775584 (-)
CBA/J	ENSMUSG00210038718	protein coding gene	Chr9:118786059-118885817 (-)
DBA/2J	ENSMUSG00185015616	protein coding gene	Chr9:119121716-119221467 (-)
FVB/NJ	ENSMUSG00205020425	protein coding gene	Chr9:118959204-119060463 (-)
JF1/MsJ	ENSUMUG00000036057	protein coding gene	Chr9:118942909-119043981 (-)
LP/J	ENSMUSG00230036469	protein coding gene	Chr9:119271948-119371738 (-)
NOD/ShiLtJ	ENSMUSG00190014007	protein coding gene	Chr9:118727072-118826862 (-)
NZO/HlLtJ	ENSMUSG00225022879	protein coding gene	Chr9:119532332-119632088 (-)
PWK/PhJ	ENSLUMG00010029361	protein coding gene	Chr9:118831537-118934575 (-)
SPRET/EiJ	ENSMSPG00010020312	protein coding gene	Chr9:120543899-120659059 (-)
WSB/EiJ	ENSIUOG00005019260	protein coding gene	Chr9:118152655-118253898 (-)

Human Ortholog

ANO10, anoctamin 10

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANO10, anoctamin 10
Synonyms

SCAR10, TMEM16K
Links

HGNC:25519

NCBI Gene ID: 55129

UniProt: Q9NW15
Chr Location

3p22.1-p21.33; chr3:43354859-43691594 (-) GRCh38

MGI Vertebrate Homology

Ano10 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ANO10
Gene Tree

Ano10

Diseases

1 with human ANO10 associations

				Human Disease	Mouse Models
				autosomal recessive spinocerebellar ataxia 10 IDs autosomal recessive spinocerebellar ataxia 10 DOID:0050999 OMIM:613728

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

4
Gene trapped

3
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele fail to exhibit calcium-activated chloride ion secretion in the jejunum.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

668
Tissues

67
cDNA Data

43
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ano10

ZFIN ano10a

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All Sequences

80
RefSeq

12
UniProt

5
CCDS

CCDS23645.1, CCDS90687.1

Ensembl

ENSMUSG00000037949 (Evidence)
NCBI Gene

102566

			Length	Strain/Species	Flank
genomic	102566	NCBI Gene Model \| MGI Sequence Detail	118483	C57BL/6J	± kb
transcript	NM_001421552	RefSeq \| MGI Sequence Detail	2675	C57BL/6
polypeptide	Q8BH79	UniProt \| EBI \| MGI Sequence Detail	659	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004056 anoctamin-10

(term hierarchy)
InterPro Domains

IPR007632 Anoctamin

IPR049452 Anoctamin, transmembrane domain
GlyGen

Q8BH79 1 site, 1 N-linked glycan (1 site)

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All nucleic 43

cDNA 43

Microarray probesets 3

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 11
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ano10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92091	Chr9:122123475-122123497 (-)	-46 bp
Tssr92090	Chr9:122123427-122123473 (-)	-10 bp
Tssr92089	Chr9:122123409-122123421 (-)	25 bp
Tssr92088	Chr9:122016671-122016700 (-)	106,754 bp
Tssr92087	Chr9:122016628-122016636 (-)	106,808 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24