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Ano10 Gene Detail
Summary
  • Symbol
    Ano10
  • Name
    anoctamin 10
  • Synonyms
    Tmem16k
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143103
    NCBI Gene: 102566
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:122175874-122294423 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      118550 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 72.94 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ANO10, anoctamin 10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ANO10, anoctamin 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SCAR10, TMEM16K
  • Links
    NCBI Gene ID: 55129
    neXtProt AC: NX_Q9NW15
    UniProt: Q9NW15

  • Chr Location
    3p22.1-p21.33; chr3:43366324-43691594 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ANO10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele fail to exhibit calcium-activated chloride ion secretion in the jejunum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037949 Ensembl Gene Model | MGI Sequence Detail 118550 C57BL/6J ±  kb
    transcript ENSMUST00000042546 Ensembl | MGI Sequence Detail 2653 Not Applicable  
    polypeptide ENSMUSP00000045214 Ensembl | MGI Sequence Detail 659 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      509 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 43

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:260534 Schreiber R, et al., Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine. Pflugers Arch. 2015 Jun;467(6):1203-13

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory