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Nek5 Gene Detail
Summary
  • Symbol
    Nek5
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142824
    NCBI Gene: 330721
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:22073616-22125053 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 10.95 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142824
protein coding gene Chr8:22073615-22125418 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033444
protein coding gene Chr8:19914126-19965581 (-)
A/J MGP_AJ_G0033424
protein coding gene Chr8:19266970-19316558 (-)
AKR/J MGP_AKRJ_G0033349
protein coding gene Chr8:19894231-19945383 (-)
BALB/cJ MGP_BALBcJ_G0033420
protein coding gene Chr8:19387729-19442268 (-)
C3H/HeJ MGP_C3HHeJ_G0033134
protein coding gene Chr8:20087874-20142013 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033936
protein coding gene Chr8:20764385-20809783 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0032460
protein coding gene Chr8:19513604-19567019 (-)
CBA/J MGP_CBAJ_G0033109
protein coding gene Chr8:21591460-21638333 (-)
DBA/2J MGP_DBA2J_G0033264
protein coding gene Chr8:19237685-19284397 (-)
FVB/NJ MGP_FVBNJ_G0033208
protein coding gene Chr8:19033387-19084731 (-)
LP/J MGP_LPJ_G0033353
protein coding gene Chr8:19916016-19961156 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033251
protein coding gene Chr8:21187242-21245107 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033955
protein coding gene Chr8:19793001-19844862 (-)
PWK/PhJ MGP_PWKPhJ_G0032172
protein coding gene Chr8:18827399-18873289 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032005
protein coding gene Chr8:19183886-19233585 (-)
WSB/EiJ MGP_WSBEiJ_G0032576
protein coding gene Chr8:19989323-20048835 (-)



Homology
more
  • Human Ortholog
    NEK5, NIMA related kinase 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NEK5, NIMA related kinase 5
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 341676
    neXtProt AC: NX_Q6P3R8
    UniProt: Q6P3R8

  • Chr Location
    13q14.3; chr13:52064762-52129092 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit progressive hearing impairment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037738 Ensembl Gene Model | MGI Sequence Detail 51438 C57BL/6J ±  kb
transcript ENSMUST00000209656 Ensembl | MGI Sequence Detail 2253 Not Applicable  
polypeptide ENSMUSP00000148211 Ensembl | MGI Sequence Detail 627 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 1
  • Earliest
    J:84167 Forrest AR, et al., Exploration of the cell-cycle genes found within the RIKEN FANTOM2 data set. Genome Res. 2003 Jun;13(6B):1366-75
  • Latest
    J:234901 Potter PK, et al., Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Nat Commun. 2016;7:12444

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory