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Cog4 Gene Detail
Summary
  • Symbol
    Cog4
  • Name
    component of oligomeric golgi complex 4
  • Synonyms
    D8Ertd515e
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142808
    NCBI Gene: 102339
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111573232-111608859 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1178 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142808
 protein coding gene Chr8:111573232-111608866 (+)
129S1/SvImJ ENSMUSGG00200054491
 protein coding gene Chr8:105890680-105899189 (+)
129S1/SvImJ ENSMUSG00200013720
 protein coding gene Chr8:105877839-105883276 (+)
A/J ENSMUSGG00195054922
 protein coding gene Chr8:106203279-106211789 (+)
A/J ENSMUSG00195017779
 protein coding gene Chr8:106190441-106195880 (+)
AKR/J ENSMUSG00220015124
 protein coding gene Chr8:106332868-106338304 (+)
AKR/J ENSMUSGG00220054537
 protein coding gene Chr8:106345702-106354210 (+)
BALB/cJ ENSMUSG00180018463
 protein coding gene Chr8:106195866-106201309 (+)
BALB/cJ ENSMUSGG00180055206
 protein coding gene Chr8:106208707-106217191 (+)
C3H/HeJ ENSMUSGG00175055109
 protein coding gene Chr8:106265607-106274115 (+)
C3H/HeJ ENSMUSG00175023674
 protein coding gene Chr8:106252769-106258208 (+)
C57BL/6NJ ENSMUSGG00215055708
 protein coding gene Chr8:105868641-105877150 (+)
C57BL/6NJ ENSMUSG00215034314
 protein coding gene Chr8:105855801-105861242 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031564
 protein coding gene Chr8:101932785-101968439 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054650
 protein coding gene Chr8:106192770-106201266 (+)
CBA/J ENSMUSG00210029558
 protein coding gene Chr8:106179930-106185371 (+)
DBA/2J ENSMUSGG00185057688
 protein coding gene Chr8:112301876-112310384 (+)
DBA/2J ENSMUSG00185017042
 protein coding gene Chr8:112289041-112294477 (+)
FVB/NJ ENSMUSG00205019424
 protein coding gene Chr8:105192381-105197819 (+)
FVB/NJ ENSMUSGG00205054335
 protein coding gene Chr8:105205218-105213727 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055789
 protein coding gene Chr8:115981677-115990185 (+)
LP/J ENSMUSG00230032154
 protein coding gene Chr8:115968834-115974273 (+)
NOD/ShiLtJ ENSMUSGG00190054700
 protein coding gene Chr8:106343753-106352262 (+)
NOD/ShiLtJ ENSMUSG00190023571
 protein coding gene Chr8:106330916-106336354 (+)
NZO/HlLtJ ENSMUSGG00225055589
 protein coding gene Chr8:119332358-119340852 (+)
NZO/HlLtJ ENSMUSG00225019724
 protein coding gene Chr8:119319526-119324964 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010038760
 protein coding gene Chr8:108170208-108205894 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    COG4, component of oligomeric golgi complex 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COG4, component of oligomeric golgi complex 4
  • Synonyms
    CDG2J, COD1, SWILS
  • Links
    NCBI Gene ID: 25839
    UniProt: Q9H9E3

  • Chr Location
    16q22.1; chr16:70480567-70523560 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human COG4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    129
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031753 Ensembl Gene Model | MGI Sequence Detail 35628 C57BL/6J ±  kb
    transcript ENSMUST00000034203 Ensembl | MGI Sequence Detail 2737 Not Applicable  
    polypeptide ENSMUSP00000034203 Ensembl | MGI Sequence Detail 785 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000005687 conserved oligomeric Golgi complex subunit 4
      (term hierarchy)
    • InterPro Domains
      IPR013167 COG4 transport protein, middle alpha-helical bundle
      IPR048682 Conserved oligomeric Golgi complex subunit 4
      IPR048684 Conserved oligomeric Golgi complex subunit 4, C-terminal
      IPR048680 Conserved oligomeric Golgi complex subunit 4, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 130
      cDNA 129
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1261770
    References
    more
    • Summaries
      All 34
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory