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Gpat4 Gene Detail
Summary
  • Symbol
    Gpat4
  • Name
    glycerol-3-phosphate acyltransferase 4
  • Synonyms
    Agpat6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142716
    NCBI Gene: 102247
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:23171265-23208346 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37082 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GPAT4, glycerol-3-phosphate acyltransferase 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPAT4, glycerol-3-phosphate acyltransferase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    1-AGPAT 6, AGPAT6, LPAATZ, LPAAT-zeta, TSARG7
  • Links
    NCBI Gene ID: 137964
    neXtProt AC: NX_Q86UL3
    UniProt: Q86UL3

  • Chr Location
    8p11.21; chr8:41578188-41625001 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nursing mothers homozygous for a gene trap allele display underdeveloped mammary glands that are depleted in intracellular fat droplets and lack the ability to produce diacylglycerol- and triacylglycerol-rich milk; pups nursed by mutant mothers die neonatally unless transferred to foster mothers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000060899 VEGA Gene Model | MGI Sequence Detail 37082 C57BL/6J ±  kb
    transcript OTTMUST00000148827 VEGA | MGI Sequence Detail 5518 Not Applicable  
    polypeptide OTTMUSP00000077315 VEGA | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      54 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 223
      cDNA 221
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142801
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:242338 Pagac M, et al., SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Cell Rep. 2016 Nov 01;17(6):1546-1559

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory