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Agpat6
Gene Detail
Symbol

Name
ID
Agpat6
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
MGI:2142716
Synonyms
Gpat4
Feature Type
protein coding gene
Genetic Map
Chromosome 8
11.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:23172946-23208453 bp, - strand
From NCBI annotation of GRCm38

  35508 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32425  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Agpat6

Human
homologs
Human Homolog AGPAT6, 1-acylglycerol-3-phosphate O-acyltransferase 6
NCBI Gene ID 137964
neXtProt AC  NX_Q86UL3
Human Synonyms  1-AGPAT 6, LPAATZ, LPAAT-zeta, TSARG7
Human Chr (Location)  8p11.21; chr8:41578188-41625001 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(18) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Nursing mothers homozygous for a gene trap allele display underdeveloped mammary glands that are depleted in intracellular fat droplets and lack the ability to produce diacylglycerol- and triacylglycerol-rich milk; pups nursed by mutant mothers die neonatally unless transferred to foster mothers.
 
Interactions
Agpat6 interacts with 206 markers (Mir7-2, Mir7b, Mir10a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (40)    Tissues (27)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 14
Northern blot 26
cDNA source data(221)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(223) cDNA(221) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000031545 (Evidence)
Entrez Gene102247 (Evidence)
UniGene200898
DFCITC1573324, TC1627457, TC1635764, TC1671666, TC1738684
DoTSDT.101405289, DT.101737322, DT.110879721, DT.535076, DT.91369435
EC2.3.1.15
Consensus CDS ProjectCCDS22189.1
International Mouse Knockout Project StatusAgpat6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 102247 NCBI Gene Model | MGI Sequence Detail 35508 C57BL/6J ±  kb
transcript NM_018743 RefSeq | MGI Sequence Detail 3944 C57BL/6 
polypeptide Q8K2C8 UniProt | EBI | MGI Sequence Detail 456 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002123 Phospholipid/glycerol acyltransferase
Protein Ontology PR:000003839 glycerol-3-phosphate acyltransferase 4
Graphical View of Protein Domain Structure
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:203532 Park YK, et al., Hypoxia-inducible factor-2alpha-dependent hypoxic induction of Wnt10b expression in adipogenic cells. J Biol Chem. 2013 Sep 6;288(36):26311-22
All references(40)
Other
accession IDs
MGI:2142801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory