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Agpat6
Gene Detail
Symbol

Name
ID
Agpat6
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
MGI:2142716
Synonyms
Gpat4
Feature Type
protein coding gene
Genetic Map
Chromosome 8
11.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:23172946-23208453 bp, - strand
From Ensembl annotation of GRCm38

  35508 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32425  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AGPAT6
Gene Tree: Agpat6

Human
homologs
AGPAT6, 1-acylglycerol-3-phosphate O-acyltransferase 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 137964
neXtProt AC: NX_Q86UL3

Human Synonyms: 1-AGPAT 6, LPAATZ, LPAAT-zeta, TSARG7

Human Chr (Location): 8p11.21; chr8:41578188-41625001 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(18) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Nursing mothers homozygous for a gene trap allele display underdeveloped mammary glands that are depleted in intracellular fat droplets and lack the ability to produce diacylglycerol- and triacylglycerol-rich milk; pups nursed by mutant mothers die neonatally unless transferred to foster mothers.
 
Interactions
Agpat6 interacts with 205 markers (Mir7-2, Mir7b, Mir10a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (40)    Tissues (27)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 14
Northern blot 26
cDNA source data(221)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase agpat6    NEW 
Molecular
reagents
All nucleic(223) cDNA(221) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000031545 (Evidence)
Entrez Gene 102247 (Evidence)
UniGene 200898
DFCI TC1635764, TC1573324, TC1627457, TC1671666, TC1738684
DoTS DT.535076, DT.101405289, DT.110879721, DT.101737322, DT.91369435
EC 2.3.1.15
Consensus CDS Project CCDS22189.1
International Mouse Phenotyping Consortium Status Agpat6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031545 Ensembl Gene Model | MGI Sequence Detail 35508 C57BL/6J ±  kb
transcript ENSMUST00000167004 Ensembl | MGI Sequence Detail 3944 Not Applicable 
polypeptide ENSMUSP00000127325 Ensembl | MGI Sequence Detail 456 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(6) UniProt(6)
Polymorphisms
SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002123 Phospholipid/glycerol acyltransferase
Protein Ontology PR:000003839 glycerol-3-phosphate acyltransferase 4
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:215498 Zhang C, et al., Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor. Am J Physiol Endocrinol Metab. 2014 Aug 1;307(3):E305-15
All references(39)
Other
accession IDs
MGI:2142801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory