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Tmem189
Gene Detail
Symbol

Name
ID
Tmem189
transmembrane protein 189
MGI:2142624
Feature Type
protein coding gene
Genetic Map
Chromosome 2
87.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:167642608-167689822 bp, - strand
From VEGA annotation of GRCm38

  47215 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:33615  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TMEM189
Gene Tree: Tmem189

Human
homologs
TMEM189, transmembrane protein 189
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 387521
neXtProt AC: NX_A5PLL7

Human Synonyms: KUA

Human Chr (Location): 20q13.2; chr20:50123737-50153798 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Interactions
Tmem189 interacts with 175 markers (Mir15a, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process protein ubiquitination
Component cytoplasm, endoplasmic reticulum, ...
Function ubiquitin protein ligase activity, ubiquitin protein ligase binding
External Resources: FuncBase
Expression
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tmem189 ; ZFIN tmem189    NEW 
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000001145 (Evidence)
Ensembl Gene Model ENSMUSG00000090213 (Evidence)
Entrez Gene 407243 (Evidence)
Consensus CDS Project CCDS17104.1
International Mouse Phenotyping Consortium Status Tmem189
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001145 VEGA Gene Model | MGI Sequence Detail 47215 C57BL/6J ±  kb
transcript OTTMUST00000002235 VEGA | MGI Sequence Detail 2329 Not Applicable 
polypeptide OTTMUSP00000001085 VEGA | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019547 Kua-ubiquitin conjugating enzyme hybrid, localisation
Protein Ontology PR:000029802 transmembrane protein 189
References
(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory