Snx25 MGI Mouse Gene Detail - MGI:2142610

Symbol

Snx25
Name

sorting nexin 25
Synonyms

LOC382008, SBBI31

Feature Type

protein coding gene
IDs

MGI:2142610
NCBI Gene: 102141
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:46486298-46605196 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 26.03 cM
Mapping Data

2 experiments

SNPs within 2kb

3135 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2142610	protein coding gene	Chr8:46486298-46605535 (-)
129S1/SvImJ	ENSMUSG00200005867	protein coding gene	Chr8:41598433-41717372 (-)
A/J	ENSMUSG00195003937	protein coding gene	Chr8:42090664-42209573 (-)
AKR/J	ENSMUSG00220004318	protein coding gene	Chr8:41907425-42026336 (-)
BALB/cJ	ENSMUSG00180002849	protein coding gene	Chr8:41631691-41750596 (-)
C3H/HeJ	ENSMUSG00175004948	protein coding gene	Chr8:41760023-41878930 (-)
C57BL/6NJ	ENSMUSG00215008119	protein coding gene	Chr8:41562781-41681684 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031028	protein coding gene	Chr8:39641914-39758674 (-)
CAST/EiJ	ENSTCUG00005018991	protein coding gene	Chr8:41602559-41721679 (-)
CBA/J	ENSMUSG00210018679	protein coding gene	Chr8:41656199-41775093 (-)
DBA/2J	ENSMUSG00185005850	protein coding gene	Chr8:47502541-47621451 (-)
FVB/NJ	ENSMUSG00205002595	protein coding gene	Chr8:40785798-40904713 (-)
JF1/MsJ	ENSUMUG00000013339	protein coding gene	Chr8:49168671-49291742 (-)
LP/J	ENSMUSG00230017145	protein coding gene	Chr8:51195138-51314035 (-)
NOD/ShiLtJ	ENSMUSG00190005496	protein coding gene	Chr8:41675639-41794534 (-)
NZO/HlLtJ	ENSMUSG00225011191	protein coding gene	Chr8:54788737-54907690 (-)
PWK/PhJ	ENSLUMG00010008924	protein coding gene	Chr8:41437103-41566552 (-)
SPRET/EiJ	ENSMSPG00010005490	protein coding gene	Chr8:42302863-42420033 (-)
WSB/EiJ	ENSIUOG00005002520	protein coding gene	Chr8:42507461-42632140 (-)

Human Ortholog

SNX25, sorting nexin 25

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNX25, sorting nexin 25
Synonyms

LRP2BP-AS1, MSTP043, SBBI31
Links

HGNC:21883

NCBI Gene ID: 83891

UniProt: Q9H3E2
Chr Location

4q35.1; chr4:185204237-185390928 (+) GRCh38

MGI Vertebrate Homology

Snx25 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNX25
Gene Tree

Snx25

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

5
Genomic Mutations

1 involving Snx25
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

37

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snx25

ZFIN snx25

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All Sequences

58
RefSeq

9
UniProt

6
CCDS

CCDS22287.2, CCDS90394.1

Ensembl

ENSMUSG00000038291 (Evidence)
NCBI Gene

102141

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038291	Ensembl Gene Model \| MGI Sequence Detail	118899	C57BL/6J	± kb
transcript	ENSMUST00000110378	Ensembl \| MGI Sequence Detail	3445	Not Applicable
polypeptide	ENSMUSP00000106007	Ensembl \| MGI Sequence Detail	986	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015374 sorting nexin-25

(term hierarchy)
PDB

7WF8, 7WF9, 8HQL
InterPro Domains

IPR003114 Phox-associated domain

IPR001683 Phox homology

IPR036871 PX domain superfamily

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR044926 RGS, subdomain 2

IPR037899 SNX25, PX domain

IPR013937 Sorting nexin, C-terminal

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All nucleic 37

cDNA 37

Microarray probesets 3

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MGI:2685019, MGI:2686545

Summaries

All 39

Gene Ontology 5

Phenotypes 14
Earliest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Latest

J:377131 Isonishi A, et al., Macrophage Deficiency of Sorting Nexin 25 Suppress Plaque Formation in Atherosclerotic Lesions in Mice. Acta Histochem Cytochem. 2025 Apr 26;58(2):101-106

TSS for Snx25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81190	Chr8:46605449-46605514 (-)	-286 bp
Tssr81189	Chr8:46550821-46550825 (-)	54,373 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24