Slc7a6
Gene Detail

Symbol Name ID

Slc7a6 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 MGI:2142598

Synonyms

LAT-2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

53.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:106168875-106198704 bp, + strand From NCBI annotation of GRCm38   29830 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:62496  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a6

Human homologs

Human Homolog		SLC7A6, solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
NCBI Gene ID		9057
neXtProt AC		NX_Q92536
Human Synonyms		LAT-2, LAT3, y+LAT-2
Human Chr (Location)		16q22.1; chr16:68298419-68335726 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(23) : Targeted(3) Gene trapped(20)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	amino acid transmembrane transport, amino acid transport, ...
Component	integral to membrane, membrane, ...
Function	amino acid transmembrane transporter activity, antiporter activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (11)    Tissues (9)    Images (1)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	1
RT-PCR	10

cDNA source data(129)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(131) cDNA(129) Primer pair(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000031904 (Evidence)
Entrez Gene	330836 (Evidence)
UniGene	46749
DFCI	TC1572301, TC1589178, TC1611230, TC1615495, TC1629052, TC1631419, TC1692382
DoTS	DT.101168909, DT.101191936, DT.101364302, DT.101398574, DT.101738593, DT.110907977, DT.110907980, DT.94126812, DT.94163490, DT.99862474
NIA Mouse Gene Index	U009769
Consensus CDS Project	CCDS22631.1
International Mouse Knockout Project Status	Slc7a6

Sequences

Length	Strain/Species
genomic	330836	NCBI Gene Model | MGI Sequence Detail	29830	C57BL/6J
transcript	NM_178798	RefSeq | MGI Sequence Detail	3730	C57BL/6
polypeptide	Q8BGK6	UniProt | EBI | MGI Sequence Detail	515	Not Applicable

All sequences(65) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(89 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002293	Amino acid/polyamine transporter I
Protein Ontology	PR:000015202	Y+L amino acid transporter 2

Graphical View of Protein Domain Structure

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(33)