About   Help   FAQ
Plekhg4 Gene Detail
Summary
  • Symbol
    Plekhg4
  • Name
    pleckstrin homology and RhoGEF domain containing G4
  • Synonyms
    4931414L13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142544
    NCBI Gene: 102075
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106099906-106109494 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142544
 protein coding gene Chr8:106096272-106109494 (+)
129S1/SvImJ ENSMUSG00200014876
 protein coding gene Chr8:100379472-100389060 (+)
A/J ENSMUSG00195003645
 protein coding gene Chr8:100701977-100711565 (+)
AKR/J ENSMUSG00220014610
 protein coding gene Chr8:100835824-100845412 (+)
BALB/cJ ENSMUSG00180023066
 protein coding gene Chr8:100707734-100717323 (+)
C3H/HeJ ENSMUSG00175022756
 protein coding gene Chr8:100764486-100774074 (+)
C57BL/6NJ ENSMUSG00215028193
 protein coding gene Chr8:100378833-100388421 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031479
 protein coding gene Chr8:96500492-96510093 (+)
CAST/EiJ ENSTCUG00005023295
 protein coding gene Chr8:100145874-100155441 (+)
CBA/J ENSMUSG00210033009
 protein coding gene Chr8:100692190-100701778 (+)
DBA/2J ENSMUSG00185005382
 protein coding gene Chr8:106800983-106810571 (+)
FVB/NJ ENSMUSG00205016821
 protein coding gene Chr8:99676467-99686055 (+)
JF1/MsJ ENSUMUG00000006639
 protein coding gene Chr8:109134179-109143767 (+)
LP/J ENSMUSG00230032562
 protein coding gene Chr8:110481378-110490966 (+)
NOD/ShiLtJ ENSMUSG00190021870
 protein coding gene Chr8:100831387-100840975 (+)
NZO/HlLtJ ENSMUSG00225018516
 protein coding gene Chr8:113831946-113841534 (+)
PWK/PhJ ENSLUMG00010003716
 protein coding gene Chr8:100615180-100624782 (+)
SPRET/EiJ ENSMSPG00010031885
 protein coding gene Chr8:102694341-102703391 (+)
WSB/EiJ ENSIUOG00005031449
 protein coding gene Chr8:101504131-101513719 (+)



Homology
more
  • Human Ortholog
    PLEKHG4, pleckstrin homology and RhoGEF domain containing G4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHG4, pleckstrin homology and RhoGEF domain containing G4
  • Synonyms
    ARHGEF44, PRTPHN1, SCA4
  • Links
    NCBI Gene ID: 25894
    UniProt: Q58EX7

  • Chr Location
    16q22.1; chr16:67277510-67289499 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    607
  • Tissues
    9
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000014782 Ensembl Gene Model | MGI Sequence Detail 9589 C57BL/6J ±  kb
transcript ENSMUST00000214056 Ensembl | MGI Sequence Detail 3654 Not Applicable  
polypeptide ENSMUSP00000150574 Ensembl | MGI Sequence Detail 1217 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR035899 Dbl homology (DH) domain superfamily
    IPR000219 Dbl homology domain
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR060651 Rho guanine nucleotide exchange factor 40-like, C-terminal domain
    IPR052231 Rho guanine nucleotide exchange factor 40-related
    IPR055251 SOS1/NGEF-like, PH domain
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:357979 Takenaka N, et al., Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle. Cell Signal. 2014 Nov;26(11):2460-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory