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Ano1
Gene Detail
Symbol

Name
ID
Ano1
anoctamin 1, calcium activated chloride channel
MGI:2142149
Synonyms
Tmem16a
Feature Type
protein coding gene
Genetic Map
Chromosome 7
88.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:144588549-144751974 bp, - strand
From VEGA annotation of GRCm38

  163426 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75079  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ANO1
Gene Tree: Ano1

Human
homologs
ANO1, anoctamin 1, calcium activated chloride channel
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55107
neXtProt AC: NX_Q5XXA6

Human Synonyms: DOG1, ORAOV2, TAOS2, TMEM16A

Human Chr (Location): 11q13.3; chr11:70078302-70189545 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(6) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knockout allele exhibit postnatal death associated with aerophagia, slow postnatal weight gain, cyanosis, and abnormal tracheal morphology. Mice homozygous for a different knock-out allele exhibit proteinuria and intracellular endosomal vesicles in PTE cells.
 
Interactions
Ano1 interacts with 238 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process cation transmembrane transport, cation transport, ...
Component apical plasma membrane, chloride channel complex, ...
Function calcium activated cation channel activity, chloride channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (600)    Tissues (371)    Images (116)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 596
RT-PCR 4
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ANO1 ; Xenbase ano1    NEW 
Molecular
reagents
All nucleic(21) cDNA(17) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000030429 (Evidence)
Ensembl Gene Model ENSMUSG00000031075 (Evidence)
Entrez Gene 101772 (Evidence)
DFCI TC1574440, TC1592789, TC1596178, TC1710069
DoTS DT.101390969, DT.101736392
NIA Mouse Gene Index U029527
Consensus CDS Project CCDS40202.1, CCDS57600.1
International Mouse Phenotyping Consortium Status Ano1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030429 VEGA Gene Model | MGI Sequence Detail 163426 C57BL/6J ±  kb
transcript OTTMUST00000075352 VEGA | MGI Sequence Detail 4552 Not Applicable 
polypeptide OTTMUSP00000039478 VEGA | MGI Sequence Detail 1017 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(20) UniProt(6)
Polymorphisms
SNPs within 2kb(1294 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007632 Anoctamin/TMEM 16
Protein Ontology PR:000004055 anoctamin-1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:219999 Catalan MA, et al., A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2263-8
All references(67)
Other
accession IDs
MGI:2142269

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory