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Ano1 Gene Detail
Summary
  • Symbol
    Ano1
  • Name
    anoctamin 1, calcium activated chloride channel
  • Synonyms
    Tmem16a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142149
    NCBI Gene: 101772
  • Gene Overview
    MyGene.info: ANO1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:144588549-144751974 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1287 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142149
protein coding gene Chr7:144588549-144752045 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033290
protein coding gene Chr7:149955151-150128080 (-)
A/J MGP_AJ_G0033273
protein coding gene Chr7:145596449-145760191 (-)
AKR/J MGP_AKRJ_G0033204
protein coding gene Chr7:149700839-149866261 (-)
BALB/cJ MGP_BALBcJ_G0033273
protein coding gene Chr7:145378614-145542031 (-)
C3H/HeJ MGP_C3HHeJ_G0032987
protein coding gene Chr7:149463144-149627245 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033783
protein coding gene Chr7:155371323-155538544 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030756
protein coding gene Chr7:146757506-146917598 (-)
CAST/EiJ MGP_CASTEiJ_G0032310
protein coding gene Chr7:141773340-141947976 (-)
CBA/J MGP_CBAJ_G0032960
protein coding gene Chr7:160662056-160834525 (-)
DBA/2J MGP_DBA2J_G0033114
protein coding gene Chr7:143576813-143738509 (-)
FVB/NJ MGP_FVBNJ_G0033062
protein coding gene Chr7:143514585-143679474 (-)
LP/J MGP_LPJ_G0033206
protein coding gene Chr7:151481238-151658000 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033096
protein coding gene Chr7:161200789-161369266 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033801
protein coding gene Chr7:148667860-148831726 (-)
PWK/PhJ MGP_PWKPhJ_G0032020
protein coding gene Chr7:136883068-137050330 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031864
protein coding gene Chr7:135448263-135614286 (-)
WSB/EiJ MGP_WSBEiJ_G0032423
protein coding gene Chr7:149655280-149823959 (-)



Homology
more
  • Human Ortholog
    ANO1, anoctamin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANO1, anoctamin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DOG1, ORAOV2, TAOS2, TMEM16A
  • Links
    NCBI Gene ID: 55107
    neXtProt AC: NX_Q5XXA6
    UniProt: Q5XXA6

  • Chr Location
    11q13.3; chr11:70078302-70189545 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 75079
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANO1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 6 alleles in 8 genetic backgrounds
    1 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit postnatal death associated with aerophagia, slow postnatal weight gain, cyanosis, and abnormal tracheal morphology. Mice homozygous for a different knock-out allele exhibit proteinuria and intracellular endosomal vesicles in PTE cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031075 Ensembl Gene Model | MGI Sequence Detail 163426 C57BL/6J ±  kb
    transcript ENSMUST00000121758 Ensembl | MGI Sequence Detail 4552 Not Applicable  
    polypeptide ENSMUSP00000112616 Ensembl | MGI Sequence Detail 1017 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 18
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142269
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 15
      Gene Ontology 14
      Phenotypes 26
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:255415 He M, et al., Cytoplasmic Cl(-) couples membrane remodeling to epithelial morphogenesis. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11161-E11169

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory