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Psip1
Gene Detail
 Symbol
Name
ID
Psip1
PC4 and SFRS1 interacting protein 1
MGI:2142116
Synonyms Psip2
Feature Type protein coding gene
Genetic Map
Chromosome 4
39.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:83455680-83486459 bp, - strand
From VEGA annotation of GRCm38

  30780 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Psip1

Human
homologs
Human Homolog PSIP1, PC4 and SFRS1 interacting protein 1
NCBI Gene ID 11168
neXtProt AC  NX_O75475
Human Synonyms  DFS70, LEDGF, p52, p75, PAIP, PSIP2
Human Chr (Location)  9p22.3; chr9:15464066-15511005 (-)  GRCh38
Alleles
and
phenotypes
All alleles(11) : Gene trapped(9) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene tend to die perinatally. Survivors show reduced fertility and a variety of skeletal and behavioral abnormalities.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process mRNA 5'-splice site recognition, positive regulation of transcription from RNA polymerase II promoter, ...
Component nuclear heterochromatin, nuclear periphery, ...
Function activating transcription factor binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (73)    Tissues (21)    Images (21)
Theiler Stages: 1, 3, 11, 17, 19, 22, 23, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 58
In situ reporter (knock in) 4
Western blot 3
RT-PCR 3
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000000034 (Evidence)
Ensembl Gene ModelENSMUSG00000028484 (Evidence)
Entrez Gene101739 (Evidence)
NIA Mouse Gene IndexU025218
Consensus CDS ProjectCCDS18299.1, CCDS71412.1
International Mouse Knockout Project StatusPsip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000034 VEGA Gene Model | MGI Sequence Detail 30780 C57BL/6J ±  kb
transcript OTTMUST00000000104 VEGA | MGI Sequence Detail 3251 Not Applicable 
polypeptide OTTMUSP00000000056 VEGA | MGI Sequence Detail 528 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(8) UniProt(5)
Polymorphisms SNPs within 2kb(213 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021567 Lens epithelium-derived growth factor (LEDGF)
InterPro IPR000313 PWWP
InterPro IPR017859 Treacle-like, Treacher Collins Syndrome
Protein Ontology PR:000003418 PC4 and SFRS1-interacting protein
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:185207 Pradeepa MM, et al., Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing. PLoS Genet. 2012 May;8(5):e1002717
All references(37)
Other
accession IDs
MGI:2140137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory