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Psip1 Gene Detail
Summary
  • Symbol
    Psip1
  • Name
    PC4 and SFRS1 interacting protein 1
  • Synonyms
    Psip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142116
    NCBI Gene: 101739
Location & Maps
more
  • Sequence Map
    Chr4:83455680-83486459 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30780 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PSIP1, PC4 and SFRS1 interacting protein 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PSIP1, PC4 and SFRS1 interacting protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DFS70, LEDGF, p52, p75, PAIP, PSIP2
  • Links
    NCBI Gene ID: 11168
    neXtProt AC: NX_O75475

  • Chr Location
    9p22.3; chr9:15464066-15511005 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 2 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    2
  • Gene trapped
    9
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Psip1
  • Incidental Mutations
Mice homozygous for disruptions in this gene tend to die perinatally. Survivors show reduced fertility and a variety of skeletal and behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000034 VEGA Gene Model | MGI Sequence Detail 30780 C57BL/6J ±  kb
transcript OTTMUST00000000104 VEGA | MGI Sequence Detail 3251 Not Applicable  
polypeptide OTTMUSP00000000056 VEGA | MGI Sequence Detail 528 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    213 from dbSNP Build 137
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000003418 PC4 and SFRS1-interacting protein
  • InterPro Domains
    IPR021567 Lens epithelium-derived growth factor (LEDGF)
    IPR000313 PWWP domain
    IPR017859 Treacle-like, Treacher Collins Syndrome
Molecular
Reagents
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  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2140137
References
more
  • Summaries
    All 35
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:206632 Roberts JM, et al., Splicing factor TRA2B is required for neural progenitor survival. J Comp Neurol. 2014 Feb 1;522(2):372-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory