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Psip1
Gene Detail
Symbol

Name
ID
Psip1
PC4 and SFRS1 interacting protein 1
MGI:2142116
Synonyms
Psip2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
39.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:83455680-83486459 bp, - strand
From VEGA annotation of GRCm38

  30780 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PSIP1
Gene Tree: Psip1

Human
homologs
PSIP1, PC4 and SFRS1 interacting protein 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11168
neXtProt AC: NX_O75475

Human Synonyms: DFS70, LEDGF, p52, p75, PAIP, PSIP2

Human Chr (Location): 9p22.3; chr9:15464066-15511005 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(9) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene tend to die perinatally. Survivors show reduced fertility and a variety of skeletal and behavioral abnormalities.
 
Interactions
Psip1 interacts with 266 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (73)    Tissues (21)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 58
In situ reporter (knock in) 4
Western blot 3
RT-PCR 3
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase psip1 ; ZFIN psip1    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000000034 (Evidence)
Ensembl Gene Model ENSMUSG00000028484 (Evidence)
Entrez Gene 101739 (Evidence)
NIA Mouse Gene Index U025218
Consensus CDS Project CCDS18299.1, CCDS71412.1
International Mouse Phenotyping Consortium Status Psip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000034 VEGA Gene Model | MGI Sequence Detail 30780 C57BL/6J ±  kb
transcript OTTMUST00000000104 VEGA | MGI Sequence Detail 3251 Not Applicable 
polypeptide OTTMUSP00000000056 VEGA | MGI Sequence Detail 528 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(213 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021567 Lens epithelium-derived growth factor (LEDGF)
InterPro IPR000313 PWWP
InterPro IPR017859 Treacle-like, Treacher Collins Syndrome
Protein Ontology PR:000003418 PC4 and SFRS1-interacting protein
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:206632 Roberts JM, et al., Splicing factor TRA2B is required for neural progenitor survival. J Comp Neurol. 2014 Feb 1;522(2):372-92
All references(36)
Other
accession IDs
MGI:2140137

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory