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Nars2 Gene Detail
Summary
  • Symbol
    Nars2
  • Name
    asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142075
    NCBI Gene: 244141
Location & Maps
more
  • Sequence Map
    Chr7:96951505-97064758 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      113254 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 53.13 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NARS2, asparaginyl-tRNA synthetase 2, mitochondrial (putative)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NARS2, asparaginyl-tRNA synthetase 2, mitochondrial (putative)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    asnRS, DFNB94, SLM5
  • Links
    NCBI Gene ID: 79731
    neXtProt AC: NX_Q96I59

  • Chr Location
    11q14.1; chr11:78435961-78574864 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 57002
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NARS2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human NARS2 associations

Human Disease Mouse Models
       Combined Oxidative Phosphorylation Deficiency 24; COXPD24   OMIM: 616239
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Genomic Mutations
    3 involving Nars2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024430 VEGA Gene Model | MGI Sequence Detail 113254 C57BL/6J ±  kb
transcript OTTMUST00000059894 VEGA | MGI Sequence Detail 3778 Not Applicable  
polypeptide OTTMUSP00000029176 VEGA | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    780 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000030931 asparagine--tRNA ligase, mitochondrial
  • EC
  • InterPro Domains
    IPR006195 Aminoacyl-tRNA synthetase, class II
    IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
    IPR018150 Aminoacyl-tRNA synthetase, class II (D/K/N)-like
    IPR004522 Asparagine-tRNA ligase
    IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
    IPR012340 Nucleic acid-binding, OB-fold
    IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
Molecular
Reagents
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  • All nucleic 26
    cDNA 26

    Microarray probesets 4
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory