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Nars2 Gene Detail
Summary
  • Symbol
    Nars2
  • Name
    asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142075
    NCBI Gene: 244141
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:96951505-97064758 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 53.13 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    780 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142075
protein coding gene Chr7:96950839-97064758 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032518
protein coding gene Chr7:99642384-99757423 (+)
A/J MGP_AJ_G0032492
protein coding gene Chr7:97170396-97282839 (+)
AKR/J MGP_AKRJ_G0032428
protein coding gene Chr7:99466712-99587562 (+)
BALB/cJ MGP_BALBcJ_G0032503
protein coding gene Chr7:96860216-96975374 (+)
C3H/HeJ MGP_C3HHeJ_G0032218
protein coding gene Chr7:99844114-99959630 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033001
protein coding gene Chr7:103502247-103628973 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029996
protein coding gene Chr7:99654558-99763385 (+)
CAST/EiJ MGP_CASTEiJ_G0031545
protein coding gene Chr7:91364209-91478791 (+)
CBA/J MGP_CBAJ_G0032185
protein coding gene Chr7:107004129-107143715 (+)
DBA/2J MGP_DBA2J_G0032337
protein coding gene Chr7:95539865-95668327 (+)
FVB/NJ MGP_FVBNJ_G0032293
protein coding gene Chr7:95322621-95435383 (+)
LP/J MGP_LPJ_G0032426
protein coding gene Chr7:100964883-101076600 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032326
protein coding gene Chr7:108571664-108689897 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033023
protein coding gene Chr7:98787785-98909541 (+)
PWK/PhJ MGP_PWKPhJ_G0031263
protein coding gene Chr7:88597930-88713820 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031106
protein coding gene Chr7:86033197-86150082 (+)
WSB/EiJ MGP_WSBEiJ_G0031662
protein coding gene Chr7:99425590-99536374 (+)



Homology
more
  • Human Ortholog
    NARS2, asparaginyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NARS2, asparaginyl-tRNA synthetase 2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    asnRS, DFNB94, SLM5
  • Links
    NCBI Gene ID: 79731
    neXtProt AC: NX_Q96I59
    UniProt: Q96I59

  • Chr Location
    11q14.1; chr11:78435961-78574864 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 57002
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NARS2
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human NARS2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018995 Ensembl Gene Model | MGI Sequence Detail 113254 C57BL/6J ±  kb
    transcript ENSMUST00000044466 Ensembl | MGI Sequence Detail 3778 Not Applicable  
    polypeptide ENSMUSP00000044937 Ensembl | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 28
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/26/2020
    MGI 6.15
    The Jackson Laboratory