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Efl1 Gene Detail
Summary
  • Symbol
    Efl1
  • Name
    elongation factor like GTPase 1
  • Synonyms
    4932434J20Rik, 6030468D11Rik, D7Ertd791e, Eftud1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141969
    NCBI Gene: 101592
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:82648614-82777852 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 47.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141969
protein coding gene Chr7:82648614-82777852 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032445
protein coding gene Chr7:84780238-84909343 (+)
A/J MGP_AJ_G0032423
protein coding gene Chr7:82738539-82868853 (+)
AKR/J MGP_AKRJ_G0032359
protein coding gene Chr7:84611592-84741825 (+)
BALB/cJ MGP_BALBcJ_G0032435
protein coding gene Chr7:82403740-82529134 (+)
C3H/HeJ MGP_C3HHeJ_G0032149
protein coding gene Chr7:85187075-85316309 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032926
protein coding gene Chr7:88070933-88205575 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029936
protein coding gene Chr7:85172901-85297376 (+)
CAST/EiJ MGP_CASTEiJ_G0031476
protein coding gene Chr7:76156936-76286946 (+)
CBA/J MGP_CBAJ_G0032114
protein coding gene Chr7:91002588-91135797 (+)
DBA/2J MGP_DBA2J_G0032269
protein coding gene Chr7:81259198-81382929 (+)
FVB/NJ MGP_FVBNJ_G0032223
protein coding gene Chr7:81214528-81337424 (+)
LP/J MGP_LPJ_G0032350
protein coding gene Chr7:85989385-86125327 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032260
protein coding gene Chr7:91055000-91183974 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032946
protein coding gene Chr7:84025352-84149441 (+)
PWK/PhJ MGP_PWKPhJ_G0031196
protein coding gene Chr7:74479616-74606750 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031038
protein coding gene Chr7:71010268-71148830 (+)
WSB/EiJ MGP_WSBEiJ_G0031593
protein coding gene Chr7:84390488-84518226 (+)



Homology
more
  • Human Ortholog
    EFL1, elongation factor like GTPase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EFL1, elongation factor like GTPase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EFTUD1, FAM42A, HsT19294, RIA1, SDS2
  • Links
    NCBI Gene ID: 79631
    neXtProt AC: NX_Q7Z2Z2
    UniProt: Q7Z2Z2

  • Chr Location
    15q25.2; chr15:82130220-82262763 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11599
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EFL1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    11
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Efl1
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for an ENU-induced mutation exhibit late-onset and progressive gait abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 101592 NCBI Gene Model | MGI Sequence Detail 129239 C57BL/6J ±  kb
transcript NM_175317 RefSeq | MGI Sequence Detail 3637 C57BL/6  
polypeptide Q8C0D5 UniProt | EBI | MGI Sequence Detail 1127 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029450 elongation factor-like GTPase 1
  • InterPro Domains
    IPR035647 EF-G domain III/V-like
    IPR000640 Elongation factor EFG, domain V-like
    IPR041095 Elongation Factor G, domain II
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR020568 Ribosomal protein S5 domain 2-type fold
    IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
    IPR005225 Small GTP-binding protein domain
    IPR000795 Transcription factor, GTP-binding domain
    IPR009000 Translation protein, beta-barrel domain superfamily
Molecular
Reagents
less
  • All nucleic 60
    cDNA 59
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1289296, MGI:1921641, MGI:2142128, MGI:2142145
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 18
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:234901 Potter PK, et al., Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Nat Commun. 2016;7:12444

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory