Alg8
Gene Detail

Symbol Name ID

Alg8 asparagine-linked glycosylation 8 (alpha-1,3-glucosyltransferase) MGI:2141959

Synonyms

LOC381903, MGC:74399

Feature Type

protein coding gene

Genetic Map

Chromosome 7

53.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:97371606-97392153 bp, + strand From VEGA annotation of GRCm38   20548 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:6931  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase/dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
Gene Tree: Alg8

Human homologs

Human Homolog		ALG8, ALG8, alpha-1,3-glucosyltransferase
NCBI Gene ID		79053
neXtProt AC		NX_Q9BVK2
Human Synonyms		CDG1H
Human Chr (Location)		11q14.1; chr11:77811988-77850699 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ALG8

Alleles and phenotypes

All alleles(16) : Targeted(1) Gene trapped(15)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	protein N-linked glycosylation
Component	endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function	alpha-1,3-mannosyltransferase activity, transferase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (95)    Tissues (95)    Images (7)
Theiler Stages: 22

Assay Type	Results
RNA in situ	95

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000029538 (Evidence)
Ensembl Gene Model	ENSMUSG00000035704 (Evidence)
Entrez Gene	381903 (Evidence)
DFCI	TC1580179
DoTS	DT.103557946, DT.111017098
NIA Mouse Gene Index	U155337
EC	2.4.1.265
Consensus CDS Project	CCDS52313.1
International Mouse Knockout Project Status	Alg8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029538	VEGA Gene Model | MGI Sequence Detail	20548	C57BL/6J
transcript	OTTMUST00000073211	VEGA | MGI Sequence Detail	2007	Not Applicable
polypeptide	OTTMUSP00000037871	VEGA | MGI Sequence Detail	526	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(110 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004856	Glycosyl transferase, ALG6/ALG8
Protein Ontology	PR:000031475	probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)

Other accession IDs

MGI:2685935