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Prkd2
Gene Detail
 Symbol
Name
ID
Prkd2
protein kinase D2
MGI:2141917
Synonyms PKD2
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:16842902-16870461 bp, + strand
From NCBI annotation of GRCm38

  27560 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: protein kinase C, mu/nu/D2 types
Gene Tree: Prkd2

Human
homologs
Human Homolog PRKD2, protein kinase D2
NCBI Gene ID 25865
neXtProt AC  NX_Q9BZL6
Human Synonyms  nPKC-D2, PKD2
Human Chr (Location)  19q13.3; chr19:46674316-46717127 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit impaired IgM and IgG1 antigen responses and CD4+ and CD8+ T cell production of IL2 and IFN-gamma in response to TCR stimulation. Mice homozygous for a gene trap allele exhibit normal T lymphocyte maturation.
 
Interactions
Prkd2 interacts with 62 markers (Mir22, Mir29b-2, Mir30b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process angiogenesis, cell adhesion, ...
Component cytoplasm, Golgi apparatus, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (69)    Tissues (37)    Images (46)
Theiler Stages: 13, 15, 17, 20, 22, 23, 26
Assay TypeResults
RNA in situ 65
RT-PCR 4
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000041187 (Evidence)
Entrez Gene101540 (Evidence)
DFCITC1575806, TC1624668
DoTSDT.485195, DT.50316629, DT.99726775
NIA Mouse Gene IndexU007719
EC2.7.11.13
Consensus CDS ProjectCCDS20855.1
International Mouse Knockout Project StatusPrkd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 101540 NCBI Gene Model | MGI Sequence Detail 27560 C57BL/6J ±  kb
transcript NM_178900 RefSeq | MGI Sequence Detail 3625 C57BL/6 
polypeptide Q8BZ03 UniProt | EBI | MGI Sequence Detail 875 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(7) UniProt(2)
Polymorphisms SNPs within 2kb(184 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR015727 Protein kinase C mu-related
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013237 serine/threonine-protein kinase D2
Graphical View of Protein Domain Structure
References (Earliest) J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
(Latest) J:201159 Zhou P, et al., Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15395-400
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory