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Prkd2 Gene Detail
Summary
  • Symbol
    Prkd2
  • Name
    protein kinase D2
  • Synonyms
    PKD2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141917
    NCBI Gene: 101540
Location & Maps
more
  • Sequence Map
    Chr7:16842902-16870461 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27560 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PRKD2, protein kinase D2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PRKD2, protein kinase D2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HSPC187, nPKC-D2, PKD2
  • Links
    NCBI Gene ID: 25865
    neXtProt AC: NX_Q9BZL6

  • Chr Location
    19q13.3; chr19:46674316-46717127 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Gene trapped
    2
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for a knock-in allele exhibit impaired IgM and IgG1 antigen responses and CD4+ and CD8+ T cell production of IL2 and IFN-gamma in response to TCR stimulation. Mice homozygous for a gene trap allele exhibit normal T lymphocyte maturation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 101540 NCBI Gene Model | MGI Sequence Detail 27560 C57BL/6J ±  kb
transcript NM_178900 RefSeq | MGI Sequence Detail 3625 C57BL/6  
polypeptide Q8BZ03 UniProt | EBI | MGI Sequence Detail 875 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    184 from dbSNP Build 137
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013237 serine/threonine-protein kinase D2
  • EC
  • InterPro Domains
    IPR020454 Diacylglycerol/phorbol-ester binding
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR017441 Protein kinase, ATP binding site
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR015727 Protein kinase C mu-related
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
  • Latest
    J:201159 Zhou P, et al., Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15395-400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory