Prkd2
Gene Detail

Symbol Name ID

Prkd2 protein kinase D2 MGI:2141917

Synonyms

PKD2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

9.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:16842902-16870461 bp, + strand From NCBI annotation of GRCm38   27560 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: protein kinase C, mu/nu/D2 types
Gene Tree: Prkd2

Human homologs

Human Homolog		PRKD2, protein kinase D2
NCBI Gene ID		25865
neXtProt AC		NX_Q9BZL6
Human Synonyms		nPKC-D2, PKD2
Human Chr (Location)		19q13.3; chr19:47177573-47220384 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)
 

Mice homozygous for a knock-in allele exhibit impaired IgM and IgG1 antigen responses and CD4+ and CD8+ T cell production of IL2 and IFN-gamma in response to TCR stimulation. Mice homozygous for a gene trap allele exhibit normal T lymphocyte maturation.

 

Gene Ontology (GO) classifications

All GO classifications: (50 annotations)

Process	angiogenesis, cell adhesion, ...
Component	cytoplasm, Golgi apparatus, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (69)    Tissues (37)    Images (46)
Theiler Stages: 13, 15, 17, 20, 22, 23, 26

Assay Type	Results
RNA in situ	65
RT-PCR	4

cDNA source data(53)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(54) cDNA(53) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000041187 (Evidence)
Entrez Gene	101540 (Evidence)
UniGene	1881
DFCI	TC1575806, TC1624668
DoTS	DT.485195, DT.50316629, DT.99726775
NIA Mouse Gene Index	U007719
EC	2.7.11.13
Consensus CDS Project	CCDS20855.1
International Mouse Knockout Project Status	Prkd2

Sequences

Length	Strain/Species
genomic	101540	NCBI Gene Model | MGI Sequence Detail	27560	C57BL/6J
transcript	NM_178900	RefSeq | MGI Sequence Detail	3625	C57BL/6
polypeptide	Q8BZ03	UniProt | EBI | MGI Sequence Detail	875	Not Applicable

All sequences(34) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(102 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020454	Diacylglycerol/phorbol-ester binding
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR015727	Protein kinase C mu-related
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000013237	serine/threonine-protein kinase D2

Graphical View of Protein Domain Structure

References

(Earliest) J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
(Latest) J:174903 Konopatskaya O, et al., Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood. 2011 Jul 14;118(2):416-24
All references(35)