About   Help   FAQ
Plekhg2 Gene Detail
Summary
  • Symbol
    Plekhg2
  • Name
    pleckstrin homology domain containing, family G (with RhoGef domain) member 2
  • Synonyms
    Clg
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141874
    NCBI Gene: 101497
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28359604-28372599 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141874
protein coding gene Chr7:28359603-28372688 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031941
protein coding gene Chr7:27142339-27155345 (-)
A/J MGP_AJ_G0031920
protein coding gene Chr7:26482974-26496317 (-)
AKR/J MGP_AKRJ_G0031851
protein coding gene Chr7:27159280-27171998 (-)
BALB/cJ MGP_BALBcJ_G0031926
protein coding gene Chr7:26641770-26654708 (-)
C3H/HeJ MGP_C3HHeJ_G0031648
protein coding gene Chr7:27537508-27550927 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032391
protein coding gene Chr7:28014017-28027014 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029443
protein coding gene Chr7:27556942-27569854 (-)
CAST/EiJ MGP_CASTEiJ_G0030983
protein coding gene Chr7:20843505-20856274 (-)
CBA/J MGP_CBAJ_G0031611
protein coding gene Chr7:29282755-29295708 (-)
DBA/2J MGP_DBA2J_G0031764
protein coding gene Chr7:26246400-26259225 (-)
FVB/NJ MGP_FVBNJ_G0031721
protein coding gene Chr7:26314504-26327247 (-)
LP/J MGP_LPJ_G0031845
protein coding gene Chr7:27466278-27479157 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031756
protein coding gene Chr7:28773860-28786804 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032421
protein coding gene Chr7:26644397-26658407 (-)
PWK/PhJ MGP_PWKPhJ_G0030706
protein coding gene Chr7:21247792-21261123 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030541
protein coding gene Chr7:17649270-17662511 (-)
WSB/EiJ MGP_WSBEiJ_G0031090
protein coding gene Chr7:26973786-26986752 (-)



Homology
more
  • Human Ortholog
    PLEKHG2, pleckstrin homology and RhoGEF domain containing G2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PLEKHG2, pleckstrin homology and RhoGEF domain containing G2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARHGEF42, CLG, CTB-60E11.4, LDAMD
  • Links
    NCBI Gene ID: 64857
    neXtProt AC: NX_Q9H7P9
    UniProt: Q9H7P9

  • Chr Location
    19q13.2; chr19:39412582-39428415 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037552 Ensembl Gene Model | MGI Sequence Detail 12996 C57BL/6J ±  kb
transcript ENSMUST00000121085 Ensembl | MGI Sequence Detail 4649 Not Applicable  
polypeptide ENSMUSP00000113449 Ensembl | MGI Sequence Detail 1365 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR035899 Dbl homology (DH) domain superfamily
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
less
  • All nucleic 98
    cDNA 98

    Microarray probesets 3
References
more
  • Summaries
    All 23
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:74401 Himmel KL, et al., Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias. J Biol Chem. 2002 Apr 19;277(16):13463-72
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory