About   Help   FAQ
Inpp5f Gene Detail
Summary
  • Symbol
    Inpp5f
  • Name
    inositol polyphosphate-5-phosphatase F
  • Synonyms
    5830435P03Rik, cI-27, mKIAA0966, SAC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141867
    NCBI Gene: 101490
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:128611328-128696425 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 70.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    541 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141867
protein coding gene Chr7:128610778-128696437 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033085
protein coding gene Chr7:133044778-133133593 (+)
A/J MGP_AJ_G0033067
protein coding gene Chr7:129473810-129561370 (+)
AKR/J MGP_AKRJ_G0032999
protein coding gene Chr7:132865550-132952313 (+)
BALB/cJ MGP_BALBcJ_G0033068
protein coding gene Chr7:129130490-129215425 (+)
C3H/HeJ MGP_C3HHeJ_G0032782
protein coding gene Chr7:132743107-132831501 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033578
protein coding gene Chr7:138232884-138317431 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030550
protein coding gene Chr7:130635213-130723417 (+)
CAST/EiJ MGP_CASTEiJ_G0032112
protein coding gene Chr7:124531493-124626612 (+)
CBA/J MGP_CBAJ_G0032755
protein coding gene Chr7:142975897-143069591 (+)
DBA/2J MGP_DBA2J_G0032907
protein coding gene Chr7:127451430-127537239 (+)
FVB/NJ MGP_FVBNJ_G0032860
protein coding gene Chr7:127316398-127401847 (+)
LP/J MGP_LPJ_G0033001
protein coding gene Chr7:134519883-134607138 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032892
protein coding gene Chr7:143986758-144075206 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033597
protein coding gene Chr7:131819621-131908631 (+)
PWK/PhJ MGP_PWKPhJ_G0031818
protein coding gene Chr7:120469458-120555331 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031664
protein coding gene Chr7:118629921-118718389 (+)
WSB/EiJ MGP_WSBEiJ_G0032223
protein coding gene Chr7:132800668-132887763 (+)



Homology
more
  • Human Ortholog
    INPP5F, inositol polyphosphate-5-phosphatase F
  • Vertebrate Orthologs
    10
  • Human Ortholog
    INPP5F, inositol polyphosphate-5-phosphatase F
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hSAC2, MSTP007, MSTPO47, SAC2
  • Links
    NCBI Gene ID: 22876
    neXtProt AC: NX_Q9Y2H2
    UniProt: Q9Y2H2

  • Chr Location
    10q26.11; chr10:119704395-119829151 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8962
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: INPP5F
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit increased isoproterenol-induced cardiac hypertrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042105 Ensembl Gene Model | MGI Sequence Detail 85098 C57BL/6J ±  kb
    transcript ENSMUST00000043138 Ensembl | MGI Sequence Detail 4734 Not Applicable  
    polypeptide ENSMUSP00000045910 Ensembl | MGI Sequence Detail 1132 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 18
      Primer pair 7
      Other 6

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1930728
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 7
    • Earliest
      J:66308 Takahashi Y, et al., Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):385-94
    • Latest
      J:231296 Bai D, et al., Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart. Sci Rep. 2016;6:22068

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory