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Ric8
Gene Detail
Symbol

Name
ID
Ric8
resistance to inhibitors of cholinesterase 8 homolog (C. elegans)
MGI:2141866
Synonyms
RIC-8, synembryn
Feature Type
protein coding gene
Genetic Map
Chromosome 7
86.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:140856957-140863730 bp, + strand
From VEGA annotation of GRCm38

  6774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23331  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RIC8A
Gene Tree: Ric8

Human
homologs
RIC8A, RIC8 guanine nucleotide exchange factor A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 60626
neXtProt AC: NX_Q9NPQ8

Human Synonyms: RIC8

Human Chr (Location): 11p15.5; chr11:207511-215175 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality during gastrulation. Heterozygotes exhibit impaired spatial learning and increased anxiety.
 
Interactions
Ric8 interacts with 192 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (169)    Tissues (79)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 35
RNA in situ 82
In situ reporter (knock in) 52
cDNA source data(114)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN ric8a    NEW 
Molecular
reagents
All nucleic(115) cDNA(115)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023444 (Evidence)
Ensembl Gene Model ENSMUSG00000025485 (Evidence)
Entrez Gene 101489 (Evidence)
UniGene 281916
DFCI TC1572238, TC1591724
NIA Mouse Gene Index U008938
Consensus CDS Project CCDS21988.1
International Mouse Phenotyping Consortium Status Ric8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023444 VEGA Gene Model | MGI Sequence Detail 6774 C57BL/6J ±  kb
transcript OTTMUST00000056992 VEGA | MGI Sequence Detail 3406 Not Applicable 
polypeptide OTTMUSP00000027447 VEGA | MGI Sequence Detail 530 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR019318 Guanine nucleotide exchange factor, Ric8
InterPro IPR008376 Synembryn
Protein Ontology PR:000013995 synembryn-A
References
(Earliest) J:70989 Miller KG, et al., RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. Neuron. 2000 Aug;27(2):289-99
(Latest) J:206422 Ruisu K, et al., Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death. PLoS One. 2013;8(8):e74031
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory