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Ric8
Gene Detail
 Symbol
Name
ID
Ric8
resistance to inhibitors of cholinesterase 8 homolog (C. elegans)
MGI:2141866
Synonyms RIC-8, synembryn
Feature Type protein coding gene
Genetic Map
Chromosome 7
86.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:140856957-140863730 bp, + strand
From VEGA annotation of GRCm38

  6774 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23331  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ric8

Human
homologs
Human Homolog RIC8A, RIC8 guanine nucleotide exchange factor A
NCBI Gene ID 60626
neXtProt AC  NX_Q9NPQ8
Human Synonyms  RIC8
Human Chr (Location)  11p15.5; chr11:207499-215175 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality during gastrulation. Heterozygotes exhibit impaired spatial learning and increased anxiety.
 
Interactions
Ric8 interacts with 192 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, basement membrane organization, ...
Component cytoplasm, cytosol, ...
Function G-protein alpha-subunit binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (169)    Tissues (79)    Images (47)
Theiler Stages: 8, 9, 10, 11, 13, 15, 17, 20, 23, 28
Assay TypeResults
Immunohistochemistry 35
RNA in situ 82
In situ reporter (knock in) 52
cDNA source data(114)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(115) cDNA(115)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023444 (Evidence)
Ensembl Gene ModelENSMUSG00000025485 (Evidence)
Entrez Gene101489 (Evidence)
UniGene281916
DFCITC1572238, TC1591724
NIA Mouse Gene IndexU008938
Consensus CDS ProjectCCDS21988.1
International Mouse Knockout Project StatusRic8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023444 VEGA Gene Model | MGI Sequence Detail 6774 C57BL/6J ±  kb
transcript OTTMUST00000056992 VEGA | MGI Sequence Detail 3406 Not Applicable 
polypeptide OTTMUSP00000027447 VEGA | MGI Sequence Detail 530 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR019318 Guanine nucleotide exchange factor, Ric8
InterPro IPR008376 Synembryn
Protein Ontology PR:000013995 synembryn-A
References (Earliest) J:70989 Miller KG, et al., RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. Neuron. 2000 Aug;27(2):289-99
(Latest) J:191222 Ma S, et al., Ric-8a, a guanine nucleotide exchange factor for heterotrimeric G proteins, regulates bergmann glia-basement membrane adhesion during cerebellar foliation. J Neurosci. 2012 Oct 24;32(43):14979-93
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory