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Atf5
Gene Detail
Symbol

Name
ID
Atf5
activating transcription factor 5
MGI:2141857
Synonyms
AFTA, Atf7, Atfx, ODA-10
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:44812257-44816658 bp, - strand
From VEGA annotation of GRCm38

  4402 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32142  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: cyclic AMP-dependent transcription factor, ATF4 type
Gene Tree: Atf5

Human
homologs
Human Homolog ATF5, activating transcription factor 5
NCBI Gene ID 22809
neXtProt AC  NX_Q9Y2D1
Human Synonyms  ATFX, HMFN0395
Human Chr (Location)  19q13.3; chr19:49928702-49933936 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit partial neonatal and postnatal lethality, absence of gastric milk in some mice, decreased body weight in mice that survive and loss of mature olfactory sensory neurons with increased apoptosis in olfactory epithelium.
 
Phenotype Images(1)
Interactions
Atf5 interacts with 74 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process multicellular organism growth, negative regulation of apoptotic process, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, heat shock protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (290)    Tissues (157)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 290
cDNA source data(137)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(138) cDNA(137) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021114 (Evidence)
Ensembl Gene ModelENSMUSG00000038539 (Evidence)
Entrez Gene107503 (Evidence)
UniGene389890
DFCITC1595421, TC1575371
DoTSDT.94367120, DT.94349774, DT.40187287
NIA Mouse Gene IndexU028500
Consensus CDS ProjectCCDS21215.1
International Mouse Knockout Project StatusAtf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021114 VEGA Gene Model | MGI Sequence Detail 4402 C57BL/6J ±  kb
transcript OTTMUST00000049970 VEGA | MGI Sequence Detail 1735 Not Applicable 
polypeptide OTTMUSP00000023254 VEGA | MGI Sequence Detail 283 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(3) UniProt(5)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
Protein Ontology PR:000004401 cyclic AMP-dependent transcription factor ATF-5
References
(Earliest) J:2973 Nishizawa M, et al., cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. FEBS Lett. 1992 Mar 24;299(1):36-8
(Latest) J:208245 Torres-Peraza JF, et al., Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus. Brain. 2013 Apr;136(Pt 4):1161-76
All references(51)
Other
accession IDs
MGD-MRK-1446, MGI:1858966, MGI:88097

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory