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Frmd4b Gene Detail
Summary
  • Symbol
    Frmd4b
  • Name
    FERM domain containing 4B
  • Synonyms
    6030440G05Rik, GRSP1, mKIAA1013
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141794
    NCBI Gene: 232288
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:97286867-97617541 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 44.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2091 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141794
 protein coding gene Chr6:97286867-97617657 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031077
 protein coding gene Chr6:99118396-99465183 (-)
A/J MGP_AJ_G0031046
 protein coding gene Chr6:95375593-95708038 (-)
AKR/J MGP_AKRJ_G0030977
 protein coding gene Chr6:98003372-98331268 (-)
BALB/cJ MGP_BALBcJ_G0031057
 protein coding gene Chr6:95340828-95666850 (-)
C3H/HeJ MGP_C3HHeJ_G0030651
 protein coding gene Chr6:86095352-86436038 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031516
 protein coding gene Chr6:101636757-101992043 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028680
 protein coding gene Chr6:93231582-93563572 (-)
CAST/EiJ MGP_CASTEiJ_G0030164
 protein coding gene Chr6:98178048-98525777 (-)
CBA/J MGP_CBAJ_G0030743
 protein coding gene Chr6:105511796-105876141 (-)
DBA/2J MGP_DBA2J_G0030896
 protein coding gene Chr6:94515116-94849271 (-)
FVB/NJ MGP_FVBNJ_G0030850
 protein coding gene Chr6:93694775-94027289 (-)
LP/J MGP_LPJ_G0030976
 protein coding gene Chr6:99162214-99499043 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030884
 protein coding gene Chr6:109424359-109778247 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031543
 protein coding gene Chr6:97869938-98211593 (-)
PWK/PhJ MGP_PWKPhJ_G0029880
 protein coding gene Chr6:93494744-93826783 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029708
 protein coding gene Chr6:96774004-97115515 (-)
WSB/EiJ MGP_WSBEiJ_G0030248
 protein coding gene Chr6:98338659-98692848 (-)



Homology
more
  • Human Ortholog
    FRMD4B, FERM domain containing 4B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FRMD4B, FERM domain containing 4B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    6030440G05Rik, GRSP1
  • Links
    NCBI Gene ID: 23150
    neXtProt AC: NX_Q9Y2L6
    UniProt: Q9Y2L6

  • Chr Location
    3p14.1; chr3:69168782-69541340 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    106
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030064 Ensembl Gene Model | MGI Sequence Detail 330675 C57BL/6J ±  kb
transcript ENSMUST00000032146 Ensembl | MGI Sequence Detail 3159 Not Applicable  
polypeptide ENSMUSP00000032146 Ensembl | MGI Sequence Detail 1035 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 106
    cDNA 106

    Microarray probesets 5
Other
Accession IDs
less
MGI:2141785
References
more
  • Summaries
    All 37
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:263912 Kong Y, et al., A FRMD4B variant suppresses dysplastic photoreceptor lesions in models of enhanced S-cone syndrome and of Nrl deficiency. Hum Mol Genet. 2018 Jun 27;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/26/2019
MGI 6.14 		The Jackson Laboratory