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Frmd4b Gene Detail
Summary
  • Symbol
    Frmd4b
  • Name
    FERM domain containing 4B
  • Synonyms
    6030440G05Rik, GRSP1, mKIAA1013
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141794
    NCBI Gene: 232288
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:97263828-97594502 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 44.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15911 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141794
 protein coding gene Chr6:97263828-97594618 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031077
 protein coding gene Chr6:99118396-99465183 (-)
A/J MGP_AJ_G0031046
 protein coding gene Chr6:95375593-95708038 (-)
AKR/J MGP_AKRJ_G0030977
 protein coding gene Chr6:98003372-98331268 (-)
BALB/cJ MGP_BALBcJ_G0031057
 protein coding gene Chr6:95340828-95666850 (-)
C3H/HeJ MGP_C3HHeJ_G0030651
 protein coding gene Chr6:86095352-86436038 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031516
 protein coding gene Chr6:101636757-101992043 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028680
 protein coding gene Chr6:93231582-93563572 (-)
CAST/EiJ MGP_CASTEiJ_G0030164
 protein coding gene Chr6:98178048-98525777 (-)
CBA/J MGP_CBAJ_G0030743
 protein coding gene Chr6:105511796-105876141 (-)
DBA/2J MGP_DBA2J_G0030896
 protein coding gene Chr6:94515116-94849271 (-)
FVB/NJ MGP_FVBNJ_G0030850
 protein coding gene Chr6:93694775-94027289 (-)
LP/J MGP_LPJ_G0030976
 protein coding gene Chr6:99162214-99499043 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030884
 protein coding gene Chr6:109424359-109778247 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031543
 protein coding gene Chr6:97869938-98211593 (-)
PWK/PhJ MGP_PWKPhJ_G0029880
 protein coding gene Chr6:93494744-93826783 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029708
 protein coding gene Chr6:96774004-97115515 (-)
WSB/EiJ MGP_WSBEiJ_G0030248
 protein coding gene Chr6:98338659-98692848 (-)



Homology
more
  • Human Ortholog
    FRMD4B, FERM domain containing 4B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRMD4B, FERM domain containing 4B
  • Synonyms
    6030440G05Rik, GRSP1
  • Links
    NCBI Gene ID: 23150
    UniProt: Q9Y2L6

  • Chr Location
    3p14.1; chr3:69168782-69542586 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    33
  • cDNA Data
    106
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030064 Ensembl Gene Model | MGI Sequence Detail 330675 C57BL/6J ±  kb
    transcript ENSMUST00000032146 Ensembl | MGI Sequence Detail 3159 Not Applicable  
    polypeptide ENSMUSP00000032146 Ensembl | MGI Sequence Detail 1035 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 106

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141785
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory