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Fbxl14 Gene Detail
Summary
  • Symbol
    Fbxl14
  • Name
    F-box and leucine-rich repeat protein 14
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141676
    NCBI Gene: 101358
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:119479668-119482630 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 56.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141676
protein coding gene Chr6:119479668-119483886 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031195
protein coding gene Chr6:122285617-122289682 (+)
A/J MGP_AJ_G0031164
protein coding gene Chr6:117602338-117605290 (+)
AKR/J MGP_AKRJ_G0031095
protein coding gene Chr6:120749507-120752391 (+)
BALB/cJ MGP_BALBcJ_G0031175
protein coding gene Chr6:117374885-117377872 (+)
C3H/HeJ MGP_C3HHeJ_G0030535
protein coding gene Chr6:63542146-63545306 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031633
protein coding gene Chr6:125426238-125429119 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028794
protein coding gene Chr6:114523063-114526017 (+)
CAST/EiJ MGP_CASTEiJ_G0030282
protein coding gene Chr6:121200055-121203017 (+)
CBA/J MGP_CBAJ_G0030858
protein coding gene Chr6:130374951-130377772 (+)
DBA/2J MGP_DBA2J_G0031014
protein coding gene Chr6:116507007-116510254 (+)
FVB/NJ MGP_FVBNJ_G0030966
protein coding gene Chr6:115625463-115629305 (+)
LP/J MGP_LPJ_G0031093
protein coding gene Chr6:122295760-122299691 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031000
protein coding gene Chr6:134380872-134384836 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031662
protein coding gene Chr6:120799571-120804437 (+)
PWK/PhJ MGP_PWKPhJ_G0029997
protein coding gene Chr6:115520861-115523930 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029826
protein coding gene Chr6:119514181-119517114 (+)
WSB/EiJ MGP_WSBEiJ_G0030365
protein coding gene Chr6:121070962-121073876 (+)



Homology
more
  • Human Ortholog
    FBXL14, F-box and leucine rich repeat protein 14
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FBXL14, F-box and leucine rich repeat protein 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Fbl14
  • Links
    NCBI Gene ID: 144699
    neXtProt AC: NX_Q8N1E6
    UniProt: Q8N1E6

  • Chr Location
    12p13.33; chr12:1565993-1594189 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030019 Ensembl Gene Model | MGI Sequence Detail 2963 C57BL/6J ±  kb
transcript ENSMUST00000032094 Ensembl | MGI Sequence Detail 2963 Not Applicable  
polypeptide ENSMUSP00000032094 Ensembl | MGI Sequence Detail 400 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 45

    Microarray probesets 2
References
more
  • Summaries
    All 22
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:253425 Chen F, et al., The E3 ubiquitin ligase SCF(FBXL14) complex stimulates neuronal differentiation by targeting the Notch signaling factor HES1 for proteolysis. J Biol Chem. 2017 Dec 8;292(49):20100-20112

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory