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Kcp Gene Detail
Summary
  • Symbol
    Kcp
  • Name
    kielin/chordin-like protein
  • Synonyms
    Crim2, KCP, LOC333088
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141640
    NCBI Gene: 333088
Location & Maps
more
  • Sequence Map
    Chr6:29473162-29507952 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34791 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.36 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KCP, kielin/chordin-like protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KCP, kielin/chordin-like protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRIM2, KCP1, NET67
  • Links
    NCBI Gene ID: 375616
    neXtProt AC: NX_Q6ZWJ8

  • Chr Location
    7q32.1; chr7:128868934-128910719 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display increased sensitivity to renal injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034248 VEGA Gene Model | MGI Sequence Detail 34791 C57BL/6J ±  kb
transcript OTTMUST00000086982 VEGA | MGI Sequence Detail 4885 Not Applicable  
polypeptide OTTMUSP00000047160 VEGA | MGI Sequence Detail 1550 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    78 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000005872 cysteine-rich motor neuron 2 protein
  • InterPro Domains
    IPR031132 Kielin/chordin-like protein
    IPR002919 Trypsin Inhibitor-like, cysteine rich domain
    IPR014853 Uncharacterised domain, cysteine-rich
    IPR001846 von Willebrand factor, type D domain
    IPR001007 VWFC domain
Molecular
Reagents
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  • All nucleic 23
    cDNA 23

    Microarray probesets 3
Other
Accession IDs
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MGI:2685639
References
more
  • Summaries
    All 23
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:97529 Lin J, et al., Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat Med. 2005 Apr;11(4):387-93
  • Latest
    J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory