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Tsen2
Gene Detail
Symbol

Name
ID
Tsen2
tRNA splicing endonuclease 2 homolog (S. cerevisiae)
MGI:2141599
Synonyms
MGC:69703
Feature Type
protein coding gene
Genetic Map
Chromosome 6
53.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:115544664-115578350 bp, + strand
From VEGA annotation of GRCm38

  33687 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41622  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: TSEN2
Protein SuperFamily: tRNA-splicing endonuclease, SEN2 subunit
Gene Tree: Tsen2

Human
homologs
TSEN2, TSEN2 tRNA splicing endonuclease subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 80746
neXtProt AC: NX_Q8NCE0

Human Synonyms: PCH2B, SEN2, SEN2L

Human Chr (Location): 3p25.2; chr3:12484432-12539622 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TSEN2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(9) Spontaneous(1)
Genomic Mutations involving Tsen2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Tsen2 interacts with 54 markers (Mir18, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process mRNA processing, RNA phosphodiester bond hydrolysis, endonucleolytic, ...
Component centrosome, cytoplasm, ...
Function lyase activity, nuclease activity, ...
External Resources: FuncBase
Expression
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tsen2    NEW 
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(26)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000023781 (Evidence)
Ensembl Gene Model ENSMUSG00000042389 (Evidence)
Entrez Gene 381802 (Evidence)
UniGene 291208
DFCI TC1581288, TC1622398
DoTS DT.55275381, DT.99841340
NIA Mouse Gene Index U007294
EC 4.6.1.16
Consensus CDS Project CCDS20440.1
International Mouse Phenotyping Consortium Status Tsen2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023781 VEGA Gene Model | MGI Sequence Detail 33687 C57BL/6J ±  kb
transcript OTTMUST00000058109 VEGA | MGI Sequence Detail 1828 Not Applicable 
polypeptide OTTMUSP00000028111 VEGA | MGI Sequence Detail 460 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(321 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011856 tRNA endonuclease-like domain
InterPro IPR006677 tRNA intron endonuclease, catalytic domain-like
InterPro IPR006678 tRNA intron endonuclease, N-terminal
InterPro IPR006676 tRNA-splicing endonuclease
InterPro IPR016589 tRNA-splicing endonuclease, SEN2 subunit
Protein Ontology PR:000016715 tRNA-splicing endonuclease subunit Sen2
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:160892 Bopp SE, et al., Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival. PLoS One. 2010;5(5):e10903
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory