Tsen2
Gene Detail

Symbol Name ID

Tsen2 tRNA splicing endonuclease 2 homolog (S. cerevisiae) MGI:2141599

Synonyms

MGC:69703

Feature Type

protein coding gene

Genetic Map

Chromosome 6

53.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:115544664-115578350 bp, + strand From VEGA annotation of GRCm38   33687 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41622  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tRNA-splicing endonuclease, SEN2 subunit
Gene Tree: Tsen2

Human homologs

Human Homolog		TSEN2, tRNA splicing endonuclease 2 homolog (S. cerevisiae)
NCBI Gene ID		80746
neXtProt AC		NX_Q8NCE0
Human Synonyms		PCH2B, SEN2, SEN2L
Human Chr (Location)		3p25.2; chr3:12525931-12574820 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TSEN2

Alleles and phenotypes

All alleles(9) : Gene trapped(9)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	mRNA processing, tRNA processing, ...
Component	centrosome, cytoplasm, ...
Function	endonuclease activity, hydrolase activity, ...

External Resources: FuncBase

Expression

cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(1) cDNA(29)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000023781 (Evidence)
Ensembl Gene Model	ENSMUSG00000042389 (Evidence)
Entrez Gene	381802 (Evidence)
UniGene	291208
DFCI	TC1581288, TC1622398
DoTS	DT.55275381, DT.99841340
NIA Mouse Gene Index	U007294
EC	3.1.27.9
Consensus CDS Project	CCDS20440.1
International Mouse Knockout Project Status	Tsen2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023781	VEGA Gene Model | MGI Sequence Detail	33687	C57BL/6J
transcript	OTTMUST00000058109	VEGA | MGI Sequence Detail	1828	Not Applicable
polypeptide	OTTMUSP00000028111	VEGA | MGI Sequence Detail	460	Not Applicable

All sequences(31) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(254 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011856	Endonuclease TnsA, N-terminal/resolvase Hjc/tRNA endonuclease, C-terminal
InterPro	IPR006677	tRNA intron endonuclease, catalytic domain-like
InterPro	IPR006678	tRNA intron endonuclease, N-terminal
InterPro	IPR016589	tRNA-splicing endonuclease, SEN2 subunit
Protein Ontology	PR:000016715	tRNA-splicing endonuclease subunit Sen2

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:160892 Bopp SE, et al., Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival. PLoS One. 2010;5(5):e10903
All references(30)