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Tsen2 Gene Detail
Summary
  • Symbol
    Tsen2
  • Name
    tRNA splicing endonuclease subunit 2
  • Synonyms
    MGC:69703
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141599
    NCBI Gene: 381802
  • Gene Overview
    MyGene.info: TSEN2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:115544703-115578340 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 53.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141599
protein coding gene Chr6:115544664-115578628 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031149
protein coding gene Chr6:118169559-118204988 (+)
A/J MGP_AJ_G0031118
protein coding gene Chr6:113632959-113666891 (+)
AKR/J MGP_AKRJ_G0031049
protein coding gene Chr6:116693632-116728638 (+)
BALB/cJ MGP_BALBcJ_G0031129
protein coding gene Chr6:113447485-113481855 (+)
C3H/HeJ MGP_C3HHeJ_G0030579
protein coding gene Chr6:67575834-67610589 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031588
protein coding gene Chr6:121177503-121212845 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028752
protein coding gene Chr6:110644797-110684767 (+)
CAST/EiJ MGP_CASTEiJ_G0030236
protein coding gene Chr6:117051354-117088622 (+)
CBA/J MGP_CBAJ_G0030815
protein coding gene Chr6:125940706-125974380 (+)
DBA/2J MGP_DBA2J_G0030968
protein coding gene Chr6:112565724-112599773 (+)
FVB/NJ MGP_FVBNJ_G0030922
protein coding gene Chr6:111734533-111770916 (+)
LP/J MGP_LPJ_G0031048
protein coding gene Chr6:118189914-118224905 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030956
protein coding gene Chr6:130139363-130174696 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031615
protein coding gene Chr6:116706022-116744445 (+)
PWK/PhJ MGP_PWKPhJ_G0029952
protein coding gene Chr6:111573789-111608440 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029780
protein coding gene Chr6:115413472-115458757 (+)
WSB/EiJ MGP_WSBEiJ_G0030320
protein coding gene Chr6:116964623-117000086 (+)



Homology
more
  • Human Ortholog
    TSEN2, tRNA splicing endonuclease subunit 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TSEN2, tRNA splicing endonuclease subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PCH2B, SEN2, SEN2L
  • Links
    NCBI Gene ID: 80746
    neXtProt AC: NX_Q8NCE0
    UniProt: Q8NCE0

  • Chr Location
    3p25.2; chr3:12484432-12539624 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TSEN2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 381802 NCBI Gene Model | MGI Sequence Detail 33638 C57BL/6J ±  kb
transcript NM_199033 RefSeq | MGI Sequence Detail 1801 C57BL/6  
polypeptide Q6P7W5 UniProt | EBI | MGI Sequence Detail 460 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 1
    cDNA 27

    Microarray probesets 4
References
more
  • Summaries
    All 29
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory