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Wdr91 Gene Detail
Summary
  • Symbol
    Wdr91
  • Name
    WD repeat domain 91
  • Synonyms
    9530020G05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141558
    NCBI Gene: 101240
  • Gene Overview
    MyGene.info: WDR91
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:34880426-34910831 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 15.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141558
protein coding gene Chr6:34880426-34910876 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030565
protein coding gene Chr6:32990440-33022881 (-)
A/J MGP_AJ_G0030538
protein coding gene Chr6:31572143-31602576 (-)
AKR/J MGP_AKRJ_G0030465
protein coding gene Chr6:32646073-32676679 (-)
BALB/cJ MGP_BALBcJ_G0030548
protein coding gene Chr6:31753015-31784051 (-)
C3H/HeJ MGP_C3HHeJ_G0030261
protein coding gene Chr6:32594307-32625464 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031002
protein coding gene Chr6:33809126-33840623 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028214
protein coding gene Chr6:29665043-29695373 (-)
CAST/EiJ MGP_CASTEiJ_G0029663
protein coding gene Chr6:32419815-32453126 (-)
CBA/J MGP_CBAJ_G0030239
protein coding gene Chr6:35119620-35149981 (-)
DBA/2J MGP_DBA2J_G0030383
protein coding gene Chr6:31451608-31482569 (-)
FVB/NJ MGP_FVBNJ_G0030337
protein coding gene Chr6:31243237-31274023 (-)
LP/J MGP_LPJ_G0030470
protein coding gene Chr6:33101651-33134639 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030373
protein coding gene Chr6:37442084-37473579 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031032
protein coding gene Chr6:32520136-32550527 (-)
PWK/PhJ MGP_PWKPhJ_G0029377
protein coding gene Chr6:31068854-31100740 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029213
protein coding gene Chr6:32203991-32234253 (-)
WSB/EiJ MGP_WSBEiJ_G0029739
protein coding gene Chr6:32450204-32494229 (-)



Homology
more
  • Human Ortholog
    WDR91, WD repeat domain 91
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WDR91, WD repeat domain 91
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSPC049, SORF1, SORF-1
  • Links
    NCBI Gene ID: 29062
    neXtProt AC: NX_A4D1P6
    UniProt: A4D1P6

  • Chr Location
    7q33; chr7:135183838-135211564 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8562
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: WDR91
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null alle exhibit neonatal lethality associated with intraabdominal bleeding. Mice homozygous for a conditional allele activated in neurons exhibit premature death, decreased brain size and weight, neuron apoptosis and reduced complexity and length of neurites.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 101240 NCBI Gene Model | MGI Sequence Detail 30406 C57BL/6J ±  kb
    transcript NM_001013366 RefSeq | MGI Sequence Detail 2759 FVB/N  
    polypeptide Q7TMQ7 UniProt | EBI | MGI Sequence Detail 748 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141521
    References
    more
    • Summaries
      All 26
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:247712 Liu K, et al., WDR91 is a Rab7 effector required for neuronal development. J Cell Biol. 2017 Oct 02;216(10):3307-3321

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/26/2020
    MGI 6.15
    The Jackson Laboratory