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Jazf1 Gene Detail
Summary
  • Symbol
    Jazf1
  • Name
    JAZF zinc finger 1
  • Synonyms
    Jaz1, Tip27
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141450
    NCBI Gene: 231986
  • Gene Overview
    MyGene.info: JAZF1
Location & Maps
more
  • Sequence Map
    Chr6:52768797-53068631 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      299835 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.74 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    JAZF1, JAZF zinc finger 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    JAZF1, JAZF zinc finger 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TIP27, ZNF802
  • Links
    NCBI Gene ID: 221895
    neXtProt AC: NX_Q86VZ6

  • Chr Location
    7p15.2-p15.1; chr7:27830573-28180818 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 18291
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: JAZF1
  • Gene Tree
    Jazf1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    21
  • Tissues
    11
  • cDNA Data
    23
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023834 VEGA Gene Model | MGI Sequence Detail 299835 C57BL/6J ±  kb
transcript OTTMUST00000058219 VEGA | MGI Sequence Detail 2203 Not Applicable  
polypeptide OTTMUSP00000028177 VEGA | MGI Sequence Detail 243 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1671 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009209 juxtaposed with another zinc finger protein 1
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
less
  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:229430 Yuasa K, et al., JAZF1 promotes proliferation of C2C12 cells, but retards their myogenic differentiation through transcriptional repression of MEF2C and MRF4-Implications for the role of Jazf1 variants in oncogenesis and type 2 diabetes. Exp Cell Res. 2015 Aug 15;336(2):287-97
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory