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Lrrc8b Gene Detail
Summary
  • Symbol
    Lrrc8b
  • Name
    leucine rich repeat containing 8 family, member B
  • Synonyms
    2210408K08Rik, R75581
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141353
    NCBI Gene: 433926
Location & Maps
more
  • Sequence Map
    Chr5:105415775-105490074 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74300 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 50.68 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LRRC8B, leucine rich repeat containing 8 family member B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LRRC8B, leucine rich repeat containing 8 family member B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TALRRP, TA-LRRP
  • Links
    NCBI Gene ID: 23507
    neXtProt AC: NX_Q6P9F7

  • Chr Location
    1p22.2; chr1:89524144-89601539 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    3 involving Lrrc8b
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053870 VEGA Gene Model | MGI Sequence Detail 74300 C57BL/6J ±  kb
transcript OTTMUST00000134038 VEGA | MGI Sequence Detail 6726 Not Applicable  
polypeptide OTTMUSP00000071155 VEGA | MGI Sequence Detail 803 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    416 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917430
References
more
  • Summaries
    All 24
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory