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Kctd10 Gene Detail
Summary
  • Symbol
    Kctd10
  • Name
    potassium channel tetramerisation domain containing 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141207
    NCBI Gene: 330171
Location & Maps
more
  • Sequence Map
    Chr5:114363567-114380508 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16942 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.99 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KCTD10, potassium channel tetramerization domain containing 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCTD10, potassium channel tetramerization domain containing 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTBD28, hBACURD3, MSTP028, ULRO61
  • Links
    NCBI Gene ID: 83892
    neXtProt AC: NX_Q9H3F6

  • Chr Location
    12q24.11; chr12:109448655-109477350 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    12
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Kctd10
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit embryonic lethality between E10.5 and E11.5, abnormal vasculature, absent vitelline circulation, enlarged pericardium, thin myocardium and defective heart valve defect formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014437 VEGA Gene Model | MGI Sequence Detail 16942 C57BL/6J ±  kb
transcript OTTMUST00000034253 VEGA | MGI Sequence Detail 1026 Not Applicable  
polypeptide OTTMUSP00000015336 VEGA | MGI Sequence Detail 316 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    169 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029298 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR011333 SKP1/BTB/POZ domain
Molecular
Reagents
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  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
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MGI:2141336
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 18
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:225134 Ren K, et al., KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development. PLoS One. 2014;9(11):e112275

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory