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Mlxip Gene Detail
Summary
  • Symbol
    Mlxip
  • Name
    MLX interacting protein
  • Synonyms
    bHLHe36, Mir, mKIAA0867, Mondoa
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141183
    NCBI Gene: 208104
Location & Maps
more
  • Sequence Map
    Chr5:123394798-123457932 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63135 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.95 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MLXIP, MLX interacting protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MLXIP, MLX interacting protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHe36, MIR, MONDOA
  • Links
    NCBI Gene ID: 22877
    neXtProt AC: NX_Q9HAP2

  • Chr Location
    12q24.31; chr12:122078728-122147347 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 22851
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MLXIP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Mlxip
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025921 VEGA Gene Model | MGI Sequence Detail 63135 C57BL/6J ±  kb
transcript OTTMUST00000063903 VEGA | MGI Sequence Detail 7303 Not Applicable  
polypeptide OTTMUSP00000031675 VEGA | MGI Sequence Detail 917 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    327 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000010459 MLX-interacting protein
  • InterPro Domains
    IPR032648 MLX-interacting protein
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 98
    Genomic 1
    cDNA 97

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:80612 Eilers AL, et al., A Novel Heterodimerization Domain, CRM1, and 14-3-3 Control Subcellular Localization of the MondoA-Mlx Heterocomplex. Mol Cell Biol. 2002 Dec;22(24):8514-26
  • Latest
    J:217834 Imamura M, et al., MondoA deficiency enhances sprint performance in mice. Biochem J. 2014 Nov 15;464(1):35-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory