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Kpna7 Gene Detail
Summary
  • Symbol
    Kpna7
  • Name
    karyopherin alpha 7 (importin alpha 8)
  • Synonyms
    importin alpha 2, LOC381686
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141165
    NCBI Gene: 381686
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr5:144983727-145009636 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 84.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141165
protein coding gene Chr5:144983519-145084030 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030354
protein coding gene Chr5:150378043-150505518 (-)
A/J MGP_AJ_G0030323
protein coding gene Chr5:143905526-144040032 (-)
AKR/J MGP_AKRJ_G0030255
protein coding gene Chr5:148396019-148512354 (-)
BALB/cJ MGP_BALBcJ_G0030340
protein coding gene Chr5:145184144-145294657 (-)
C3H/HeJ MGP_C3HHeJ_G0030051
protein coding gene Chr5:149214133-149338825 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030785
protein coding gene Chr5:155864986-155995385 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028004
protein coding gene Chr5:137677854-137778098 (-)
CAST/EiJ MGP_CASTEiJ_G0029456
protein coding gene Chr5:148780997-148903116 (-)
CBA/J MGP_CBAJ_G0030021
protein coding gene Chr5:162259214-162432195 (-)
DBA/2J MGP_DBA2J_G0030171
protein coding gene Chr5:143646547-143755677 (-)
FVB/NJ MGP_FVBNJ_G0030126
protein coding gene Chr5:142866900-142902540 (-)
LP/J MGP_LPJ_G0030257
protein coding gene Chr5:150965228-151088118 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030157
protein coding gene Chr5:164593838-164738665 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030825
protein coding gene Chr5:148301423-148413893 (-)
PWK/PhJ MGP_PWKPhJ_G0029171
protein coding gene Chr5:142785799-142904711 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029007
protein coding gene Chr5:146035064-146163757 (-)
WSB/EiJ MGP_WSBEiJ_G0029529
protein coding gene Chr5:149097928-149222262 (-)



Homology
more
  • Human Ortholog
    KPNA7, karyopherin subunit alpha 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KPNA7, karyopherin subunit alpha 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPOA8
  • Links
    NCBI Gene ID: 402569
    neXtProt AC: NX_A9QM74
    UniProt: A9QM74

  • Chr Location
    chr7:99145467-99219417 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a null mutation display smaller litter sizes with preferential loss of females and accelerated cell cycles post fertilization resulting in loss of embryos.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381686 NCBI Gene Model | MGI Sequence Detail 25910 C57BL/6J ±  kb
    transcript NM_001013774 RefSeq | MGI Sequence Detail 2248 Not Specified  
    polypeptide C0LLJ0 UniProt | EBI | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2685901
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 2
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:241220 Bertram S, et al., H7N9 Influenza A Virus Exhibits Importin-alpha7-Mediated Replication in the Mammalian Respiratory Tract. Am J Pathol. 2017 Apr;187(4):831-840

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    08/13/2019
    MGI 6.14
    The Jackson Laboratory