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Alkbh2 Gene Detail
Summary
  • Symbol
    Alkbh2
  • Name
    alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
  • Synonyms
    Abh2, mABH2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141032
    NCBI Gene: 231642
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114123926-114128218 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141032
protein coding gene Chr5:114123926-114130544 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029931
protein coding gene Chr5:116837324-116841592 (-)
A/J MGP_AJ_G0029896
protein coding gene Chr5:112254177-112258490 (-)
AKR/J MGP_AKRJ_G0029834
protein coding gene Chr5:115820015-115824304 (-)
BALB/cJ MGP_BALBcJ_G0029907
protein coding gene Chr5:113622468-113626761 (-)
C3H/HeJ MGP_C3HHeJ_G0029627
protein coding gene Chr5:116307701-116311988 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030361
protein coding gene Chr5:121355364-121359650 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027589
protein coding gene Chr5:107079196-107083495 (-)
CAST/EiJ MGP_CASTEiJ_G0029035
protein coding gene Chr5:115243858-115248152 (-)
CBA/J MGP_CBAJ_G0029594
protein coding gene Chr5:125952734-125957028 (-)
DBA/2J MGP_DBA2J_G0029744
protein coding gene Chr5:112313283-112317701 (-)
FVB/NJ MGP_FVBNJ_G0029701
protein coding gene Chr5:111109372-111114713 (-)
LP/J MGP_LPJ_G0029833
protein coding gene Chr5:117406299-117410585 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029732
protein coding gene Chr5:130430399-130434689 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030402
protein coding gene Chr5:115276355-115282800 (-)
PWK/PhJ MGP_PWKPhJ_G0028749
protein coding gene Chr5:110941633-110946309 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028587
protein coding gene Chr5:112816603-112822589 (-)
WSB/EiJ MGP_WSBEiJ_G0029111
protein coding gene Chr5:115840888-115845207 (-)



Homology
more
  • Human Ortholog
    ALKBH2, alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALKBH2, alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ABH2
  • Links
    NCBI Gene ID: 121642
    neXtProt AC: NX_Q6NS38
    UniProt: Q6NS38

  • Chr Location
    12q24.11; chr12:109088188-109093631 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18393
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ALKBH2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and overtly normal but show progressive accumulation of 1-methyladenine (1meA) in their genomic DNA due to impaired DNA repair. Mutant MEFs fail to remove methyl methane sulfate (MMS)-induced 1meA from genomic DNA and showincreased cytotoxicity after MMS exposure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044339 Ensembl Gene Model | MGI Sequence Detail 4293 C57BL/6J ±  kb
transcript ENSMUST00000053657 Ensembl | MGI Sequence Detail 1073 Not Applicable  
polypeptide ENSMUSP00000056043 Ensembl | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:190468 Calvo JA, et al., DNA repair is indispensable for survival after acute inflammation. J Clin Invest. 2012 Jul 2;122(7):2680-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory