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Alkbh2 Gene Detail
Summary
  • Symbol
    Alkbh2
  • Name
    alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
  • Synonyms
    Abh2, mABH2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141032
    NCBI Gene: 231642
Location & Maps
more
  • Sequence Map
    Chr5:114123926-114128218 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4293 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.97 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ALKBH2, alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALKBH2, alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABH2
  • Links
    NCBI Gene ID: 121642
    neXtProt AC: NX_Q6NS38

  • Chr Location
    12q24.11; chr12:109088188-109093631 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 18393
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ALKBH2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    63
  • Chemically induced (other)
    1
  • Gene trapped
    58
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Alkbh2
  • Incidental Mutations
Homozygous null mice are viable and overtly normal but show progressive accumulation of 1-methyladenine (1meA) in their genomic DNA due to impaired DNA repair. Mutant MEFs fail to remove methyl methane sulfate (MMS)-induced 1meA from genomic DNA and showincreased cytotoxicity after MMS exposure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014449 VEGA Gene Model | MGI Sequence Detail 4293 C57BL/6J ±  kb
transcript OTTMUST00000034280 VEGA | MGI Sequence Detail 1073 Not Applicable  
polypeptide OTTMUSP00000015347 VEGA | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    75 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 9
    cDNA 9

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:190468 Calvo JA, et al., DNA repair is indispensable for survival after acute inflammation. J Clin Invest. 2012 Jul 2;122(7):2680-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory