Ube3c MGI Mouse Gene Detail - MGI:2140998 - ubiquitin protein ligase E3C

Symbol

Ube3c
Name

ubiquitin protein ligase E3C
Synonyms

mKIAA0010

Feature Type

protein coding gene
IDs

MGI:2140998
NCBI Gene: 100763
Gene Overview

MyGene.info: UBE3C
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:29569242-29676077 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 15.12 cM
Mapping Data

1 experiment

SNPs within 2kb

372 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140998	protein coding gene	Chr5:29569242-29676092 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029377	protein coding gene	Chr5:27504435-27613298 (+)
A/J	MGP_AJ_G0029343	protein coding gene	Chr5:26585310-26695712 (+)
AKR/J	MGP_AKRJ_G0029294	protein coding gene	Chr5:27661719-27768399 (+)
BALB/cJ	MGP_BALBcJ_G0029354	protein coding gene	Chr5:27119177-27227402 (+)
C3H/HeJ	MGP_C3HHeJ_G0029075	protein coding gene	Chr5:27679575-27797905 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029807	protein coding gene	Chr5:29167254-29280596 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027045	protein coding gene	Chr5:24143166-24252947 (+)
CAST/EiJ	MGP_CASTEiJ_G0028486	protein coding gene	Chr5:26791095-26900092 (+)
CBA/J	MGP_CBAJ_G0029043	protein coding gene	Chr5:29704229-29817029 (+)
DBA/2J	MGP_DBA2J_G0029192	protein coding gene	Chr5:26786050-26892890 (+)
FVB/NJ	MGP_FVBNJ_G0029150	protein coding gene	Chr5:26194974-26304184 (+)
LP/J	MGP_LPJ_G0029277	protein coding gene	Chr5:27941305-28053455 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029179	protein coding gene	Chr5:30687364-30807884 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029841	protein coding gene	Chr5:27243625-27354505 (+)
PWK/PhJ	MGP_PWKPhJ_G0028210	protein coding gene	Chr5:25896882-26005214 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028041	protein coding gene	Chr5:26533668-26648459 (+)
WSB/EiJ	MGP_WSBEiJ_G0028566	protein coding gene	Chr5:27274110-27383147 (+)

Human Ortholog

UBE3C, ubiquitin protein ligase E3C

Vertebrate Orthologs

10

Human Ortholog

UBE3C, ubiquitin protein ligase E3C
Orthology source: HomoloGene, HGNC
Synonyms

HECTH2
Links

HGNC:16803

NCBI Gene ID: 9690

neXtProt AC: NX_Q15386

UniProt: Q15386
Chr Location

7q36.3; chr7:157138952-157269372 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8783
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: UBE3C
Gene Tree

Ube3c

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References

1 with disease annotations

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Phenotype Summary

17 phenotypes from 1 allele in 1 genetic background
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Chemically induced (other)

2
Gene trapped

26
Radiation induced

3
Spontaneous

1
Targeted

3
Genomic Mutations

6 involving Ube3c
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

53 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1279
Tissues

156
cDNA Data

202
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube3c

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Ube3c interacts with 314 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

50
RefSeq

2
UniProt

2
CCDS

CCDS39042.1
UniGene

137746

Ensembl

ENSMUSG00000039000 (Evidence)
NCBI Gene

100763

			Length	Strain/Species	Flank
genomic	100763	NCBI Gene Model \| MGI Sequence Detail	106836	C57BL/6J	± kb
transcript	NM_133907	RefSeq \| MGI Sequence Detail	5033	C57BL/6
polypeptide	Q80U95	UniProt \| EBI \| MGI Sequence Detail	1083	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016994 ubiquitin-protein ligase E3C

(term hierarchy)
EC

2.3.2.26
InterPro Domains

IPR000569 HECT domain

IPR035983 HECT, E3 ligase catalytic domain

IPR000048 IQ motif, EF-hand binding site

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All nucleic 203

cDNA 202

Primer pair 1

Microarray probesets 6

Summaries

All 59

Developmental Gene Expression 4

Diseases 1

Gene Ontology 4

Phenotypes 33
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:265666 Fratta P, et al., Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. EMBO J. 2018 Jun 1;37(11)

TSS for Ube3c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45535	Chr5:29569208-29569267 (+)	-4 bp
Tssr45536	Chr5:29569342-29569354 (+)	106 bp
Tssr45537	Chr5:29569438-29569448 (+)	201 bp
Tssr45538	Chr5:29569449-29569459 (+)	212 bp
Tssr45539	Chr5:29569463-29569481 (+)	230 bp
Tssr45540	Chr5:29569490-29569499 (+)	253 bp
Tssr45541	Chr5:29569820-29569830 (+)	583 bp
Tssr45542	Chr5:29569838-29569853 (+)	604 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2021 MGI 6.16