Ube3c MGI Mouse Gene Detail - MGI:2140998 - ubiquitin protein ligase E3C

Ube3c Gene Detail

Symbol

Ube3c
Name

ubiquitin protein ligase E3C
Synonyms

mKIAA0010

Feature Type

protein coding gene
IDs

MGI:2140998
NCBI Gene: 100763
Gene Overview

MyGene.info: UBE3C

Sequence Map

Chr5:29569242-29676092 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

106851 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 15.12 cM
Mapping Data

1 experiment

Human Ortholog

UBE3C, ubiquitin protein ligase E3C

Vertebrate Orthologs

10

Human Ortholog

UBE3C, ubiquitin protein ligase E3C
Orthology source: HomoloGene, HGNC
Synonyms

HECTH2
Links

HGNC:16803

NCBI Gene ID: 9690

neXtProt AC: NX_Q15386
Chr Location

7q36.3; chr7:157138959-157269372 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 8783
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: UBE3C
Gene Tree

Ube3c

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References

1 with disease annotations

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Phenotype Summary

18 phenotypes from 1 allele in 1 genetic background
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Chemically induced (other)

2
Gene trapped

26
Radiation induced

4
Spontaneous

1
Targeted

3
Genomic Mutations

7 involving Ube3c
Incidental Mutations

Mutagenetix , APF

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All GO Annotations

17
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

198
Tissues

103
cDNA Data

201
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase ube3c

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Ube3c interacts with 314 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS39042.1
UniGene

137746

			Length	Strain/Species	Flank
genomic	OTTMUSG00000054280	VEGA Gene Model \| MGI Sequence Detail	106851	C57BL/6J	± kb
transcript	OTTMUST00000134693	VEGA \| MGI Sequence Detail	5048	Not Applicable
polypeptide	OTTMUSP00000071408	VEGA \| MGI Sequence Detail	1083	Not Applicable

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SNPs within 2kb

372 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000016994 ubiquitin-protein ligase E3C
EC

6.3.2.-
InterPro Domains

IPR000569 HECT domain

IPR000048 IQ motif, EF-hand binding site

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All nucleic 202

cDNA 201

Primer pair 1

Microarray probesets 6

Summaries

All 36

Developmental Gene Expression 3

Diseases 1

Gene Ontology 4

Phenotypes 32
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
Latest

J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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