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Ube3c Gene Detail
Summary
  • Symbol
    Ube3c
  • Name
    ubiquitin protein ligase E3C
  • Synonyms
    mKIAA0010
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140998
    NCBI Gene: 100763
  • Gene Overview
    MyGene.info: UBE3C
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:29569242-29676077 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 15.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    372 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140998
protein coding gene Chr5:29569242-29676092 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029377
protein coding gene Chr5:27504435-27613298 (+)
A/J MGP_AJ_G0029343
protein coding gene Chr5:26585310-26695712 (+)
AKR/J MGP_AKRJ_G0029294
protein coding gene Chr5:27661719-27768399 (+)
BALB/cJ MGP_BALBcJ_G0029354
protein coding gene Chr5:27119177-27227402 (+)
C3H/HeJ MGP_C3HHeJ_G0029075
protein coding gene Chr5:27679575-27797905 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029807
protein coding gene Chr5:29167254-29280596 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027045
protein coding gene Chr5:24143166-24252947 (+)
CAST/EiJ MGP_CASTEiJ_G0028486
protein coding gene Chr5:26791095-26900092 (+)
CBA/J MGP_CBAJ_G0029043
protein coding gene Chr5:29704229-29817029 (+)
DBA/2J MGP_DBA2J_G0029192
protein coding gene Chr5:26786050-26892890 (+)
FVB/NJ MGP_FVBNJ_G0029150
protein coding gene Chr5:26194974-26304184 (+)
LP/J MGP_LPJ_G0029277
protein coding gene Chr5:27941305-28053455 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029179
protein coding gene Chr5:30687364-30807884 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029841
protein coding gene Chr5:27243625-27354505 (+)
PWK/PhJ MGP_PWKPhJ_G0028210
protein coding gene Chr5:25896882-26005214 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028041
protein coding gene Chr5:26533668-26648459 (+)
WSB/EiJ MGP_WSBEiJ_G0028566
protein coding gene Chr5:27274110-27383147 (+)



Homology
more
  • Human Ortholog
    UBE3C, ubiquitin protein ligase E3C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBE3C, ubiquitin protein ligase E3C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HECTH2
  • Links
    NCBI Gene ID: 9690
    neXtProt AC: NX_Q15386
    UniProt: Q15386

  • Chr Location
    7q36.3; chr7:157138952-157269372 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8783
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UBE3C
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100763 NCBI Gene Model | MGI Sequence Detail 106836 C57BL/6J ±  kb
    transcript NM_133907 RefSeq | MGI Sequence Detail 5033 C57BL/6  
    polypeptide Q80U95 UniProt | EBI | MGI Sequence Detail 1083 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 203
      cDNA 202
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 4
      Phenotypes 33
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:265666 Fratta P, et al., Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. EMBO J. 2018 Jun 1;37(11)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory