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Usp30 Gene Detail
Summary
  • Symbol
    Usp30
  • Name
    ubiquitin specific peptidase 30
  • Synonyms
    6330590F17Rik, D5Ertd483e
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140991
    NCBI Gene: 100756
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114100299-114123510 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140991
protein coding gene Chr5:114065461-114124720 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029930
protein coding gene Chr5:116777873-116838118 (+)
A/J MGP_AJ_G0029895
protein coding gene Chr5:112195028-112254971 (+)
AKR/J MGP_AKRJ_G0029833
protein coding gene Chr5:115757025-115820809 (+)
BALB/cJ MGP_BALBcJ_G0029906
protein coding gene Chr5:113563704-113623262 (+)
C3H/HeJ MGP_C3HHeJ_G0029626
protein coding gene Chr5:116246014-116308491 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030360
protein coding gene Chr5:121293823-121356158 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027588
protein coding gene Chr5:107021150-107079974 (+)
CAST/EiJ MGP_CASTEiJ_G0029034
protein coding gene Chr5:115178751-115244636 (+)
CBA/J MGP_CBAJ_G0029593
protein coding gene Chr5:125885582-125953524 (+)
DBA/2J MGP_DBA2J_G0029743
protein coding gene Chr5:112254954-112314073 (+)
FVB/NJ MGP_FVBNJ_G0029700
protein coding gene Chr5:111044430-111110162 (+)
LP/J MGP_LPJ_G0029832
protein coding gene Chr5:117345632-117407093 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029731
protein coding gene Chr5:130366587-130431193 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030401
protein coding gene Chr5:115214398-115277145 (+)
PWK/PhJ MGP_PWKPhJ_G0028748
protein coding gene Chr5:110884503-110942419 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028586
protein coding gene Chr5:112757222-112817382 (+)
WSB/EiJ MGP_WSBEiJ_G0029110
protein coding gene Chr5:115780192-115841678 (+)



Homology
more
  • Human Ortholog
    USP30, ubiquitin specific peptidase 30
  • Vertebrate Orthologs
    11
  • Human Ortholog
    USP30, ubiquitin specific peptidase 30
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 84749
    neXtProt AC: NX_Q70CQ3
    UniProt: Q70CQ3

  • Chr Location
    12q24.11; chr12:109023089-109088026 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32789
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: USP30
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 100756 NCBI Gene Model | MGI Sequence Detail 23212 C57BL/6J ±  kb
transcript NM_001033202 RefSeq | MGI Sequence Detail 2790 C57BL/6  
polypeptide Q3UN04 UniProt | EBI | MGI Sequence Detail 517 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    cDNA 38
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1196355
References
more
  • Summaries
    All 40
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:211366 Yue W, et al., A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Res. 2014 Apr;24(4):482-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory