About   Help   FAQ
Take the Alliance for Genomic Resources User Survey
Mapre3 Gene Detail
Summary
  • Symbol
    Mapre3
  • Name
    microtubule-associated protein, RP/EB family, member 3
  • Synonyms
    EB3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140967
    NCBI Gene: 100732
  • Gene Overview
    MyGene.info: MAPRE3
Location & Maps
more
  • Sequence Map
    Chr5:30814641-30866106 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      51466 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 16.90 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MAPRE3, microtubule associated protein RP/EB family member 3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MAPRE3, microtubule associated protein RP/EB family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EB3, EBF3, EBF3-S, RP3
  • Links
    NCBI Gene ID: 22924
    neXtProt AC: NX_Q9UPY8

  • Chr Location
    2p23.3-p23.1; chr2:26970371-27027219 (+)  GRCh38.p2
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    6 involving Mapre3
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a conditional allele activated in endothelial cells fail to exhibit F2r agonist-induced vascular hyper-permeability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    4
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022303 VEGA Gene Model | MGI Sequence Detail 51466 C57BL/6J ±  kb
transcript OTTMUST00000053142 VEGA | MGI Sequence Detail 2021 Not Applicable  
polypeptide OTTMUSP00000025251 VEGA | MGI Sequence Detail 281 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    286 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010172 microtubule-associated protein RP/EB family member 3
  • InterPro Domains
    IPR001715 Calponin homology domain
    IPR004953 EB1, C-terminal
    IPR027738 EB3, vertebrate
    IPR027328 Microtubule-associated protein RP/EB
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 28
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:224855 Geyer M, et al., Microtubule-Associated Protein EB3 Regulates IP3 Receptor Clustering and Ca(2+) Signaling in Endothelial Cells. Cell Rep. 2015 Jul 7;12(1):79-89
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory