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Mapre3 Gene Detail
Summary
  • Symbol
    Mapre3
  • Name
    microtubule-associated protein, RP/EB family, member 3
  • Synonyms
    EB3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140967
    NCBI Gene: 100732
  • Gene Overview
    MyGene.info: MAPRE3
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:30814641-30866106 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 16.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140967
protein coding gene Chr5:30814615-30866106 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029396
protein coding gene Chr5:28769219-28821618 (+)
A/J MGP_AJ_G0029362
protein coding gene Chr5:27834331-27887522 (+)
AKR/J MGP_AKRJ_G0029313
protein coding gene Chr5:28983034-29039641 (+)
BALB/cJ MGP_BALBcJ_G0029373
protein coding gene Chr5:28357357-28409565 (+)
C3H/HeJ MGP_C3HHeJ_G0029094
protein coding gene Chr5:28977568-29031241 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029826
protein coding gene Chr5:30548029-30600014 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027064
protein coding gene Chr5:25316469-25365298 (+)
CAST/EiJ MGP_CASTEiJ_G0028505
protein coding gene Chr5:28071615-28124892 (+)
CBA/J MGP_CBAJ_G0029062
protein coding gene Chr5:31119011-31174902 (+)
DBA/2J MGP_DBA2J_G0029211
protein coding gene Chr5:28018932-28069750 (+)
FVB/NJ MGP_FVBNJ_G0029169
protein coding gene Chr5:27431583-27481735 (+)
LP/J MGP_LPJ_G0029296
protein coding gene Chr5:29232152-29288687 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029198
protein coding gene Chr5:32013060-32066453 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029860
protein coding gene Chr5:28486551-28539041 (+)
PWK/PhJ MGP_PWKPhJ_G0028229
protein coding gene Chr5:27131833-27185397 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028082
protein coding gene Chr5:28322177-28326483 (-)
WSB/EiJ MGP_WSBEiJ_G0028585
protein coding gene Chr5:28551329-28603724 (+)



Homology
more
  • Human Ortholog
    MAPRE3, microtubule associated protein RP/EB family member 3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MAPRE3, microtubule associated protein RP/EB family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EB3, EBF3, EBF3-S, RP3
  • Links
    NCBI Gene ID: 22924
    neXtProt AC: NX_Q9UPY8
    UniProt: Q9UPY8

  • Chr Location
    2p23.3; chr2:26970371-27027219 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    5 involving Mapre3
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Mice homozygous for a conditional allele activated in endothelial cells fail to exhibit F2r agonist-induced vascular hyper-permeability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029166 Ensembl Gene Model | MGI Sequence Detail 51466 C57BL/6J ±  kb
transcript ENSMUST00000031058 Ensembl | MGI Sequence Detail 2021 Not Applicable  
polypeptide ENSMUSP00000031058 Ensembl | MGI Sequence Detail 281 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 4
References
more
  • Summaries
    All 56
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 7
    Phenotypes 28
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:224855 Geyer M, et al., Microtubule-Associated Protein EB3 Regulates IP3 Receptor Clustering and Ca(2+) Signaling in Endothelial Cells. Cell Rep. 2015 Jul 7;12(1):79-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory