Mapre3 Gene Detail

Summary

• Symbol
  Mapre3
• Name
  microtubule-associated protein, RP/EB family, member 3
• Synonyms
  EB3

• Feature Type
  protein coding gene
• IDs
  MGI:2140967
  NCBI Gene: 100732
• Gene Overview
  MyGene.info: MAPRE3
• Alliance
  gene page
• Transcription Start Sites
  7 TSS

Location &
Maps

• Sequence Map
  Chr5:30814641-30866106 bp, + strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 16.90 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  286 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140967	protein coding gene	Chr5:30814615-30866106 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029396	protein coding gene	Chr5:28769219-28821618 (+)
A/J	MGP_AJ_G0029362	protein coding gene	Chr5:27834331-27887522 (+)
AKR/J	MGP_AKRJ_G0029313	protein coding gene	Chr5:28983034-29039641 (+)
BALB/cJ	MGP_BALBcJ_G0029373	protein coding gene	Chr5:28357357-28409565 (+)
C3H/HeJ	MGP_C3HHeJ_G0029094	protein coding gene	Chr5:28977568-29031241 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029826	protein coding gene	Chr5:30548029-30600014 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027064	protein coding gene	Chr5:25316469-25365298 (+)
CAST/EiJ	MGP_CASTEiJ_G0028505	protein coding gene	Chr5:28071615-28124892 (+)
CBA/J	MGP_CBAJ_G0029062	protein coding gene	Chr5:31119011-31174902 (+)
DBA/2J	MGP_DBA2J_G0029211	protein coding gene	Chr5:28018932-28069750 (+)
FVB/NJ	MGP_FVBNJ_G0029169	protein coding gene	Chr5:27431583-27481735 (+)
LP/J	MGP_LPJ_G0029296	protein coding gene	Chr5:29232152-29288687 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029198	protein coding gene	Chr5:32013060-32066453 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029860	protein coding gene	Chr5:28486551-28539041 (+)
PWK/PhJ	MGP_PWKPhJ_G0028229	protein coding gene	Chr5:27131833-27185397 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028082	protein coding gene	Chr5:28322177-28326483 (-)
WSB/EiJ	MGP_WSBEiJ_G0028585	protein coding gene	Chr5:28551329-28603724 (+)

Homology

• Human Ortholog
  MAPRE3, microtubule associated protein RP/EB family member 3

• Vertebrate Orthologs
  6

• Human Ortholog
  MAPRE3, microtubule associated protein RP/EB family member 3
  Orthology source: HomoloGene, HGNC
• Synonyms
  EB3, EBF3, EBF3-S, RP3
• Links
  HGNC:6892

  NCBI Gene ID: 22924

  neXtProt AC: NX_Q9UPY8

  UniProt: Q9UPY8

  
  
• Chr Location
  2p23.3; chr2:26970371-27027219 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 56565
  1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken
  
• HCOP
  human homology predictions: MAPRE3
• Gene Tree
  Mapre3
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 2 alleles in 2 genetic backgrounds
  28 phenotype references
  

• All Mutations and Alleles
  11
• Chemically induced (other)
  2
• Gene trapped
  2
• Radiation induced
  2
• Spontaneous
  1
• Targeted
  4
• Genomic Mutations
  5 involving Mapre3
• Incidental Mutations
  APF , CvDC
• Find Mice (IMSR)
  14 strains or lines available

Mice homozygous for a conditional allele activated in endothelial cells fail to exhibit F2r agonist-induced vascular hyper-permeability.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  36
• GO References
  6

• External Resources
  FuncBase

Expression

• cDNA Data
  5
• Literature Summary
  1

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  ZFIN mapre3b

Interactions

• Mapre3 interacts with 173 markers (Mir16-1, Mir17, Mir19a, ...) View All

Sequences &
Gene Models

• All Sequences
  72
• RefSeq
  14
• UniProt
  4
• CCDS
  CCDS19163.1, CCDS80240.1

• Ensembl
  ENSMUSG00000029166 (Evidence)
• NCBI Gene
  100732

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000029166	Ensembl Gene Model | MGI Sequence Detail	51466	C57BL/6J
transcript	ENSMUST00000031058	Ensembl | MGI Sequence Detail	2021	Not Applicable
polypeptide	ENSMUSP00000031058	Ensembl | MGI Sequence Detail	281	Not Applicable

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000010172 microtubule-associated protein RP/EB family member 3
  (term hierarchy)
• InterPro Domains
  IPR001715 Calponin homology domain
  IPR036872 CH domain superfamily
  IPR004953 EB1, C-terminal
  IPR036133 EB1, C-terminal domain superfamily
  IPR027738 EB3
  IPR042180 Intermediate filament, rod domain, coil 1B
  IPR027328 Microtubule-associated protein RP/EB

Molecular
Reagents

• All nucleic 5

  cDNA 5

  
  

  Microarray probesets 4

References

• Summaries
  All 55

  Developmental Gene Expression 1

  Diseases 1

  Gene Ontology 6

  Phenotypes 28
• Earliest
  J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
• Latest
  J:224855 Geyer M, et al., Microtubule-Associated Protein EB3 Regulates IP3 Receptor Clustering and Ca(2+) Signaling in Endothelial Cells. Cell Rep. 2015 Jul 7;12(1):79-89

TSS for Mapre3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45622	Chr5:30814571-30814617 (+)	-47 bp
Tssr45623	Chr5:30814722-30814776 (+)	108 bp
Tssr45624	Chr5:30814784-30814800 (+)	151 bp
Tssr45625	Chr5:30815049-30815060 (+)	414 bp
Tssr45626	Chr5:30853788-30853794 (+)	39,150 bp
Tssr45627	Chr5:30853796-30853801 (+)	39,158 bp
Tssr45628	Chr5:30853808-30853848 (+)	39,187 bp