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Acacb Gene Detail
Summary
  • Symbol
    Acacb
  • Name
    acetyl-Coenzyme A carboxylase beta
  • Synonyms
    Acc2, Accb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140940
    NCBI Gene: 100705
  • Gene Overview
    MyGene.info: ACACB
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114146535-114250761 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    895 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140940
protein coding gene Chr5:114146321-114250761 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029933
protein coding gene Chr5:116859920-116971015 (+)
A/J MGP_AJ_G0029898
protein coding gene Chr5:112276820-112383377 (+)
AKR/J MGP_AKRJ_G0029836
protein coding gene Chr5:115842948-115951782 (+)
BALB/cJ MGP_BALBcJ_G0029909
protein coding gene Chr5:113645080-113751625 (+)
C3H/HeJ MGP_C3HHeJ_G0029629
protein coding gene Chr5:116335447-116454319 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030363
protein coding gene Chr5:121379446-121500298 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027591
protein coding gene Chr5:107101676-107208085 (+)
CAST/EiJ MGP_CASTEiJ_G0029037
protein coding gene Chr5:115268835-115385757 (+)
CBA/J MGP_CBAJ_G0029596
protein coding gene Chr5:125985784-126118305 (+)
DBA/2J MGP_DBA2J_G0029746
protein coding gene Chr5:112335970-112444723 (+)
FVB/NJ MGP_FVBNJ_G0029703
protein coding gene Chr5:111134056-111244999 (+)
LP/J MGP_LPJ_G0029835
protein coding gene Chr5:117428909-117539602 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029734
protein coding gene Chr5:130454127-130571666 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030404
protein coding gene Chr5:115301069-115416389 (+)
PWK/PhJ MGP_PWKPhJ_G0028751
protein coding gene Chr5:110966054-111074087 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028589
protein coding gene Chr5:112844128-112954782 (+)
WSB/EiJ MGP_WSBEiJ_G0029113
protein coding gene Chr5:115866127-115983537 (+)



Homology
more
  • Human Ortholog
    ACACB, acetyl-CoA carboxylase beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACACB, acetyl-CoA carboxylase beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACC2, ACCB, HACC275
  • Links
    NCBI Gene ID: 32
    neXtProt AC: NX_O00763
    UniProt: O00763

  • Chr Location
    12q24.11; chr12:109112666-109268226 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74382
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ACACB
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable, fertile and overtly normal but exhibit high levels of fatty acid oxidation, as well as reduced fat accumulation in their adipose tissue and liver, and decreased storage of glycogen in their liver.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042010 Ensembl Gene Model | MGI Sequence Detail 104227 C57BL/6J ±  kb
    transcript ENSMUST00000102582 Ensembl | MGI Sequence Detail 8788 Not Applicable  
    polypeptide ENSMUSP00000099642 Ensembl | MGI Sequence Detail 2448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141247
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 9
      Gene Ontology 12
      Phenotypes 32
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:265924 Lepropre S, et al., AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation. Blood. 2018 Sep 13;132(11):1180-1192

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory