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Acacb
Gene Detail
 Symbol
Name
ID
Acacb
acetyl-Coenzyme A carboxylase beta
MGI:2140940
Synonyms Acc2, Accb
Feature Type protein coding gene
Genetic Map
Chromosome 5
55.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:114146535-114250761 bp, + strand
From VEGA annotation of GRCm38

  104227 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74382  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Acacb

Human
homologs
Human Homolog ACACB, acetyl-CoA carboxylase beta
NCBI Gene ID 32
neXtProt AC  NX_O00763
Human Synonyms  ACC2, ACCB, HACC275
Human Chr (Location)  12q24.11; chr12:109116431-109268226 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(12) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable, fertile and overtly normal but exhibit high levels of fatty acid oxidation, as well as reduced fat accumulation in their adipose tissue and liver, and decreased storage of glycogen in their liver.
 
Interactions
Acacb interacts with 171 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process acetyl-CoA metabolic process, fatty acid biosynthetic process, ...
Component mitochondrion, nucleus
Function acetyl-CoA carboxylase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (101)    Tissues (96)    Images (2)
Theiler Stages: 11, 22, 28
Assay TypeResults
RNA in situ 94
Western blot 3
RT-PCR 4
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014407 (Evidence)
Ensembl Gene ModelENSMUSG00000042010 (Evidence)
Entrez Gene100705 (Evidence)
NIA Mouse Gene IndexU006027
Consensus CDS ProjectCCDS19561.1
International Mouse Knockout Project StatusAcacb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014407 VEGA Gene Model | MGI Sequence Detail 104227 C57BL/6J ±  kb
transcript OTTMUST00000034129 VEGA | MGI Sequence Detail 8788 Not Applicable 
polypeptide OTTMUSP00000015299 VEGA | MGI Sequence Detail 2448 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(12) UniProt(7)
Polymorphisms SNPs within 2kb(900 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013537 Acetyl-CoA carboxylase, central domain
InterPro IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
InterPro IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
InterPro IPR011761 ATP-grasp fold
InterPro IPR013815 ATP-grasp fold, subdomain 1
InterPro IPR013816 ATP-grasp fold, subdomain 2
InterPro IPR005482 Biotin carboxylase, C-terminal
InterPro IPR011764 Biotin carboxylation domain
InterPro IPR000089 Biotin/lipoyl attachment
InterPro IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
InterPro IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
InterPro IPR000022 Carboxyl transferase
InterPro IPR016185 Pre-ATP-grasp domain
InterPro IPR011054 Rudiment single hybrid motif
InterPro IPR011053 Single hybrid motif
Protein Ontology PR:000003597 acetyl-CoA carboxylase 2
References (Earliest) J:68427 Abu-Elheiga L, et al., Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 2001 Mar 30;291(5513):2613-6
(Latest) J:185557 Hoehn KL, et al., Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice. J Biol Chem. 2012 May 4;287(19):15801; author reply 15802
All references(51)
Other
accession IDs
MGI:2141247

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory