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Gbp6 Gene Detail
Summary
  • Symbol
    Gbp6
  • Name
    guanylate binding protein 6
  • Synonyms
    Mpa2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140937
    NCBI Gene: 100702
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:105418568-105441564 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 50.68 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140937
 protein coding gene Chr5:105418568-105443733 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029822
 protein coding gene Chr5:107213236-107256583 (-)
A/J MGP_AJ_G0029785
 protein coding gene Chr5:102625497-102792442 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0029799
 protein coding gene Chr5:104098678-104167665 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0030253
 protein coding gene Chr5:111582661-111612595 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027488
 protein coding gene Chr5:98147072-98166223 (-)
CAST/EiJ MGP_CASTEiJ_G0028933
 protein coding gene Chr5:105807487-105830825 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0029636
 protein coding gene Chr5:103277733-103305912 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0029723
 protein coding gene Chr5:107542097-107564541 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029625
 protein coding gene Chr5:120356170-120447319 (-)
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0028487
 protein coding gene Chr5:103478742-103511072 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GBP6, guanylate binding protein family member 6
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GBP6, guanylate binding protein family member 6
  • Links
    NCBI Gene ID: 163351
    neXtProt AC: NX_Q6ZN66
    UniProt: Q6ZN66

  • Chr Location
    1p22.2; chr1:89364059-89388160 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    17
  • cDNA Data
    9
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000104713 Ensembl Gene Model | MGI Sequence Detail 22997 C57BL/6J ±  kb
transcript ENSMUST00000196520 Ensembl | MGI Sequence Detail 2604 Not Applicable  
polypeptide ENSMUSP00000142518 Ensembl | MGI Sequence Detail 611 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • EC
    3.6.5.-
  • InterPro Domains
    IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
    IPR003191 Guanylate-binding protein/Atlastin, C-terminal
    IPR037684 Guanylate-binding protein, C-terminal
    IPR036543 Guanylate-binding protein, C-terminal domain superfamily
    IPR015894 Guanylate-binding protein, N-terminal
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory