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Napepld Gene Detail
Summary
  • Symbol
    Napepld
  • Name
    N-acyl phosphatidylethanolamine phospholipase D
  • Synonyms
    NAPE-PLD
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140885
    NCBI Gene: 242864
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:21662901-21701396 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 9.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    437 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140885
protein coding gene Chr5:21662901-21702154 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029321
protein coding gene Chr5:19231283-19278863 (-)
A/J MGP_AJ_G0029286
protein coding gene Chr5:18601645-18643543 (-)
AKR/J MGP_AKRJ_G0029237
protein coding gene Chr5:19314887-19361981 (-)
BALB/cJ MGP_BALBcJ_G0029298
protein coding gene Chr5:19038959-19077855 (-)
C3H/HeJ MGP_C3HHeJ_G0029017
protein coding gene Chr5:19383016-19426016 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029751
protein coding gene Chr5:20635926-20677826 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026990
protein coding gene Chr5:16655051-16692566 (-)
CAST/EiJ MGP_CASTEiJ_G0028429
protein coding gene Chr5:18710597-18754618 (-)
CBA/J MGP_CBAJ_G0028984
protein coding gene Chr5:20867543-20913508 (-)
DBA/2J MGP_DBA2J_G0029136
protein coding gene Chr5:18885076-18926759 (-)
FVB/NJ MGP_FVBNJ_G0029094
protein coding gene Chr5:18291584-18331269 (-)
LP/J MGP_LPJ_G0029220
protein coding gene Chr5:19635497-19684423 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029122
protein coding gene Chr5:22138448-22181853 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029784
protein coding gene Chr5:18969060-19011055 (-)
PWK/PhJ MGP_PWKPhJ_G0028152
protein coding gene Chr5:17939581-17981886 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027985
protein coding gene Chr5:18333235-18380598 (-)
WSB/EiJ MGP_WSBEiJ_G0028509
protein coding gene Chr5:19034718-19077051 (-)



Homology
more
  • Human Ortholog
    NAPEPLD, N-acyl phosphatidylethanolamine phospholipase D
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NAPEPLD, N-acyl phosphatidylethanolamine phospholipase D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C7orf18, FMP30, NAPE-PLD
  • Links
    NCBI Gene ID: 222236
    neXtProt AC: NX_Q6IQ20
    UniProt: Q6IQ20

  • Chr Location
    7q22.1; chr7:103099576-103149560 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Chemically induced (other)
    2
  • Gene trapped
    17
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    4 involving Napepld
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a null mutation are viable and healthy, but have abnormal brain levels of N-acyl ethanolamines and N-acyl phosphatidylethanolamines.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044968 Ensembl Gene Model | MGI Sequence Detail 38496 C57BL/6J ±  kb
transcript ENSMUST00000115217 Ensembl | MGI Sequence Detail 3954 Not Applicable  
polypeptide ENSMUSP00000110872 Ensembl | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010983 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
  • EC
  • InterPro Domains
    IPR001279 Metallo-beta-lactamase
    IPR024884 N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D
    IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Molecular
Reagents
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  • All nucleic 19
    cDNA 19

    Microarray probesets 3
References
more
  • Summaries
    All 59
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 7
    Phenotypes 28
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:270178 Everard A, et al., Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis. Nat Commun. 2019 Jan 28;10(1):457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory