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Lrrc8c Gene Detail
Summary
  • Symbol
    Lrrc8c
  • Name
    leucine rich repeat containing 8 family, member C
  • Synonyms
    E430036I04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140839
    NCBI Gene: 100604
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:105519388-105613018 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 50.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    583 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140839
protein coding gene Chr5:105519345-105613018 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029826
protein coding gene Chr5:107408913-107508185 (+)
A/J MGP_AJ_G0029790
protein coding gene Chr5:103320491-103417166 (+)
AKR/J MGP_AKRJ_G0029735
protein coding gene Chr5:106679433-106775290 (+)
BALB/cJ MGP_BALBcJ_G0029802
protein coding gene Chr5:104466003-104561069 (+)
C3H/HeJ MGP_C3HHeJ_G0029524
protein coding gene Chr5:107096752-107198198 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030256
protein coding gene Chr5:111890660-111987725 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027491
protein coding gene Chr5:98420257-98521566 (+)
CAST/EiJ MGP_CASTEiJ_G0028938
protein coding gene Chr5:105990342-106090445 (+)
CBA/J MGP_CBAJ_G0029492
protein coding gene Chr5:115605636-115721689 (+)
DBA/2J MGP_DBA2J_G0029638
protein coding gene Chr5:103487377-103581337 (+)
FVB/NJ MGP_FVBNJ_G0029595
protein coding gene Chr5:102199913-102294587 (+)
LP/J MGP_LPJ_G0029726
protein coding gene Chr5:108024487-108120785 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029627
protein coding gene Chr5:120669608-120766781 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030290
protein coding gene Chr5:106212600-106308045 (+)
PWK/PhJ MGP_PWKPhJ_G0028651
protein coding gene Chr5:101953580-102052698 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028489
protein coding gene Chr5:103693552-103798578 (+)
WSB/EiJ MGP_WSBEiJ_G0029011
protein coding gene Chr5:106528072-106626194 (+)



Homology
more
  • Human Ortholog
    LRRC8C, leucine rich repeat containing 8 VRAC subunit C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRRC8C, leucine rich repeat containing 8 VRAC subunit C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AD158, FAD158
  • Links
    NCBI Gene ID: 84230
    neXtProt AC: NX_Q8TDW0
    UniProt: Q8TDW0

  • Chr Location
    1p22.2; chr1:89615810-89719535 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12997
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRRC8C
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    3 involving Lrrc8c
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit a reduction in body weight, white adipose tissue weight, and insulin resistance on a high-fat diet, indicating protection from diet-induced obesity and insulin resistance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054720 Ensembl Gene Model | MGI Sequence Detail 93631 C57BL/6J ±  kb
transcript ENSMUST00000067924 Ensembl | MGI Sequence Detail 6976 Not Applicable  
polypeptide ENSMUSP00000066015 Ensembl | MGI Sequence Detail 803 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 4
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:262352 Deneka D, et al., Structure of a volume-regulated anion channel of the LRRC8 family. Nature. 2018 May 16;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory