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Hsd17b13 Gene Detail
Summary
  • Symbol
    Hsd17b13
  • Name
    hydroxysteroid (17-beta) dehydrogenase 13
  • Synonyms
    Pan1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140804
    NCBI Gene: 243168
Location & Maps
more
  • Sequence Map
    Chr5:103955440-103977410 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21971 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 50.46 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    HSD17B13, hydroxysteroid 17-beta dehydrogenase 13
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HSD17B13, hydroxysteroid 17-beta dehydrogenase 13
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HMFN0376, NIIL497, SCDR9, SDR16C3
  • Links
    NCBI Gene ID: 345275
    neXtProt AC: NX_Q7Z5P4

  • Chr Location
    4q22.1; chr4:87303789-87322906 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Hsd17b13
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026811 VEGA Gene Model | MGI Sequence Detail 21971 C57BL/6J ±  kb
transcript OTTMUST00000066307 VEGA | MGI Sequence Detail 1708 Not Applicable  
polypeptide OTTMUSP00000033211 VEGA | MGI Sequence Detail 304 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    195 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008777 17-beta-hydroxysteroid dehydrogenase 13
  • EC
  • InterPro Domains
    IPR016040 NAD(P)-binding domain
    IPR002347 Short-chain dehydrogenase/reductase SDR
Molecular
Reagents
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  • All nucleic 21
    cDNA 21

    Microarray probesets 4
References
more
  • Summaries
    All 25
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
  • Latest
    J:212240 Su W, et al., Comparative proteomic study reveals 17beta-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11437-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory