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Slc15a4 Gene Detail
Summary
  • Symbol
    Slc15a4
  • Name
    solute carrier family 15, member 4
  • Synonyms
    C130069N12Rik, PHT1, PTR4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140796
    NCBI Gene: 100561
  • Gene Overview
    MyGene.info: SLC15A4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:127595664-127632897 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 66.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140796
protein coding gene Chr5:127595478-127632900 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030116
protein coding gene Chr5:131549823-131587705 (-)
A/J MGP_AJ_G0030083
protein coding gene Chr5:126039125-126077221 (-)
AKR/J MGP_AKRJ_G0030017
protein coding gene Chr5:130132110-130175259 (-)
BALB/cJ MGP_BALBcJ_G0030093
protein coding gene Chr5:127379969-127419026 (-)
C3H/HeJ MGP_C3HHeJ_G0029810
protein coding gene Chr5:130716983-130754072 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030546
protein coding gene Chr5:136609166-136648462 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027771
protein coding gene Chr5:120489970-120527014 (-)
CAST/EiJ MGP_CASTEiJ_G0029219
protein coding gene Chr5:129900642-129961515 (-)
CBA/J MGP_CBAJ_G0029780
protein coding gene Chr5:141963377-142002123 (-)
DBA/2J MGP_DBA2J_G0029930
protein coding gene Chr5:126037093-126074404 (-)
FVB/NJ MGP_FVBNJ_G0029886
protein coding gene Chr5:125086757-125123976 (-)
LP/J MGP_LPJ_G0030019
protein coding gene Chr5:132076058-132114827 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029917
protein coding gene Chr5:145392211-145437730 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030587
protein coding gene Chr5:129788050-129826204 (-)
PWK/PhJ MGP_PWKPhJ_G0028933
protein coding gene Chr5:124885902-124943938 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028770
protein coding gene Chr5:127322693-127379444 (-)
WSB/EiJ MGP_WSBEiJ_G0029293
protein coding gene Chr5:130454729-130491517 (-)



Homology
more
  • Human Ortholog
    SLC15A4, solute carrier family 15 member 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC15A4, solute carrier family 15 member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FP12591, PHT1, PTR4
  • Links
    NCBI Gene ID: 121260
    neXtProt AC: NX_Q8N697
    UniProt: Q8N697

  • Chr Location
    12q24.33; chr12:128793194-128823996 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation display abrogation of both Toll-like receptor (TLR)-induced type I IFN and proinflammatory cytokine production by plasmacytoid dendritic cells. Conventional dendritic cells respond normally to TLR ligands.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029416 Ensembl Gene Model | MGI Sequence Detail 37234 C57BL/6J ±  kb
transcript ENSMUST00000031367 Ensembl | MGI Sequence Detail 2732 Not Applicable  
polypeptide ENSMUSP00000031367 Ensembl | MGI Sequence Detail 574 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000014943 solute carrier family 15 member 4
  • InterPro Domains
    IPR036259 MFS transporter superfamily
    IPR000109 Proton-dependent oligopeptide transporter family
    IPR018456 PTR2 family proton/oligopeptide symporter, conserved site
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141246
References
more
  • Summaries
    All 44
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:251131 Pollard KM, et al., Induction of Systemic Autoimmunity by a Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome and Endolysosome but Not Type I IFN. J Immunol. 2017 Dec 1;199(11):3739-3747

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory