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Slc15a4
Gene Detail
Symbol

Name
ID
Slc15a4
solute carrier family 15, member 4
MGI:2140796
Synonyms
C130069N12Rik, PHT1, PTR4
Feature Type
protein coding gene
Genetic Map
Chromosome 5
66.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:127595664-127632897 bp, - strand
From VEGA annotation of GRCm38

  37234 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:26432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc15a4

Human
homologs
Human Homolog SLC15A4, solute carrier family 15 (oligopeptide transporter), member 4
NCBI Gene ID 121260
neXtProt AC  NX_Q8N697
Human Synonyms  PHT1, PTR4
Human Chr (Location)  12q24.32; chr12:128793194-128823996 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Gene trapped(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced mutation display abrogation of both Toll-like receptor (TLR)-induced type I IFN and proinflammatory cytokine production by plasmacytoid dendritic cells. Conventional dendritic cells respond normally to TLR ligands.
 
Interactions
Slc15a4 interacts with 226 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process drug transmembrane transport, histidine transport, ...
Component integral component of membrane, membrane
Function L-histidine transmembrane transporter activity, symporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000028813 (Evidence)
Ensembl Gene ModelENSMUSG00000029416 (Evidence)
Entrez Gene100561 (Evidence)
DFCITC1577141, TC1776451, TC1673481
DoTSDT.87057231, DT.110638587, DT.101140881, DT.490197
NIA Mouse Gene IndexU285398, U026751
Consensus CDS ProjectCCDS19688.1
International Mouse Knockout Project StatusSlc15a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028813 VEGA Gene Model | MGI Sequence Detail 37234 C57BL/6J ±  kb
transcript OTTMUST00000071346 VEGA | MGI Sequence Detail 2732 Not Applicable 
polypeptide OTTMUSP00000036542 VEGA | MGI Sequence Detail 574 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(9) UniProt(11)
Polymorphisms
SNPs within 2kb(303 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR000109 Proton-dependent oligopeptide transporter family
InterPro IPR018456 PTR2 family proton/oligopeptide symporter, conserved site
Protein Ontology PR:000014943 solute carrier family 15 member 4
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:194543 Baccala R, et al., Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2940-5
All references(38)
Other
accession IDs
MGI:2141246

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory