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Slc15a4 Gene Detail
Summary
  • Symbol
    Slc15a4
  • Name
    solute carrier family 15, member 4
  • Synonyms
    C130069N12Rik, PHT1, PTR4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140796
    NCBI Gene: 100561
  • Gene Overview
    MyGene.info: SLC15A4
Location & Maps
more
  • Sequence Map
    Chr5:127595664-127632897 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37234 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC15A4, solute carrier family 15 member 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC15A4, solute carrier family 15 member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FP12591, PHT1, PTR4
  • Links
    NCBI Gene ID: 121260
    neXtProt AC: NX_Q8N697

  • Chr Location
    12q24.32; chr12:128793194-128823996 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Slc15a4
  • Incidental Mutations
Mice homozygous for an ENU-induced mutation display abrogation of both Toll-like receptor (TLR)-induced type I IFN and proinflammatory cytokine production by plasmacytoid dendritic cells. Conventional dendritic cells respond normally to TLR ligands.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028813 VEGA Gene Model | MGI Sequence Detail 37234 C57BL/6J ±  kb
transcript OTTMUST00000071346 VEGA | MGI Sequence Detail 2732 Not Applicable  
polypeptide OTTMUSP00000036542 VEGA | MGI Sequence Detail 574 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    300 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000014943 solute carrier family 15 member 4
  • InterPro Domains
    IPR020846 Major facilitator superfamily domain
    IPR000109 Proton-dependent oligopeptide transporter family
    IPR018456 PTR2 family proton/oligopeptide symporter, conserved site
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141246
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 14
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:223449 Dosenovic P, et al., Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation. Immunol Cell Biol. 2015 Feb;93(2):136-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory