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Oas1d Gene Detail
Summary
  • Symbol
    Oas1d
  • Name
    2'-5' oligoadenylate synthetase 1D
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140770
    NCBI Gene: 100535
  • Gene Overview
    MyGene.info: OAS1
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr5:120914818-120921648 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 60.87 cM, cytoband F
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140770
protein coding gene Chr5:120914536-120921652 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030020
protein coding gene Chr5:124344347-124353682 (+)
A/J MGP_AJ_G0029985
protein coding gene Chr5:119200774-119207394 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0029996
protein coding gene Chr5:120625409-120632029 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0030449
protein coding gene Chr5:129061642-129066770 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0029790
protein coding gene Chr5:118241467-118248579 (+)
LP/J MGP_LPJ_G0029922
protein coding gene Chr5:124862438-124869095 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0030490
protein coding gene Chr5:122599510-122606755 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Vertebrate Orthologs
    3
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
    Orthology source: HGNC
  • Synonyms
    E18/E16, IFI-4, OIAS, OIASI
  • Links
    NCBI Gene ID: 4938
    neXtProt AC: NX_P00973
    UniProt: P00973

  • Chr Location
    12q24.13; chr12:112906777-112932190 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null females exhibit reduced fertility due to defects in ovarian follicle development and decreased efficiency of ovulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100535 NCBI Gene Model | MGI Sequence Detail 6831 C57BL/6J ±  kb
    transcript NM_133893 RefSeq | MGI Sequence Detail 1750 C57BL/6  
    polypeptide Q8VI95 UniProt | EBI | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR026774 2'-5'-oligoadenylate synthase
      IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
      IPR038121 2'-5'-oligoadenylate synthetase, domain 2 superfamily
      IPR006116 2-5-oligoadenylate synthetase, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 1
      cDNA 82
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141327
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory