Zfand2a MGI Mouse Gene Detail - MGI:2140729 - zinc finger, AN1-type domain 2A

Symbol

Zfand2a
Name

zinc finger, AN1-type domain 2A
Synonyms

Airap

Feature Type

protein coding gene
IDs

MGI:2140729
NCBI Gene: 100494
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr5:139456971-139470246 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 78.68 cM
Mapping Data

1 experiment

SNPs within 2kb

229 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140729	protein coding gene	Chr5:139456966-139470304 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030286	protein coding gene	Chr5:144455777-144470099 (-)
A/J	MGP_AJ_G0030255	protein coding gene	Chr5:138333698-138346996 (-)
AKR/J	MGP_AKRJ_G0030187	protein coding gene	Chr5:142644073-142657383 (-)
BALB/cJ	MGP_BALBcJ_G0030272	protein coding gene	Chr5:139575821-139589474 (-)
C3H/HeJ	MGP_C3HHeJ_G0029983	protein coding gene	Chr5:143418110-143431436 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030717	protein coding gene	Chr5:149782209-149795532 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027935	protein coding gene	Chr5:132193405-132206667 (-)
CAST/EiJ	MGP_CASTEiJ_G0029388	protein coding gene	Chr5:142830533-142846290 (-)
CBA/J	MGP_CBAJ_G0029953	protein coding gene	Chr5:155954831-155971152 (-)
DBA/2J	MGP_DBA2J_G0030103	protein coding gene	Chr5:138141182-138154724 (-)
FVB/NJ	MGP_FVBNJ_G0030058	protein coding gene	Chr5:137254431-137270610 (-)
LP/J	MGP_LPJ_G0030189	protein coding gene	Chr5:145063818-145078731 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030089	protein coding gene	Chr5:158612390-158625683 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030757	protein coding gene	Chr5:142455960-142470201 (-)
PWK/PhJ	MGP_PWKPhJ_G0029103	protein coding gene	Chr5:137147592-137160915 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028939	protein coding gene	Chr5:140139306-140152152 (-)
WSB/EiJ	MGP_WSBEiJ_G0029462	protein coding gene	Chr5:143222575-143235874 (-)

Human Ortholog

ZFAND2A, zinc finger AN1-type containing 2A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFAND2A, zinc finger AN1-type containing 2A
Synonyms

AIRAP
Links

HGNC:28073

NCBI Gene ID: 90637

neXtProt AC: NX_Q8N6M9

UniProt: Q8N6M9
Chr Location

7p22.3; chr7:1148850-1160759 (-) GRCh38

MGI Vertebrate Homology

Zfand2a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZFAND2A
Gene Tree

Zfand2a

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

3
Targeted

3
Find Mice (IMSR)

16 strains or lines available

Homozygous mutant mouse embryonic fibroblasts accumulate more polyubiquitylated proteins than wild-type cells and display higher levels of stress when exposed to arsenite, while isolated proteasomes are relatively impaired in substrate degradation in vitro.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

64
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zfand2a

ZFIN zfand2a

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All Sequences

53
RefSeq

4
UniProt

2
CCDS

CCDS19812.1

Ensembl

ENSMUSG00000053581 (Evidence)
NCBI Gene

100494

			Length	Strain/Species	Flank
genomic	100494	NCBI Gene Model \| MGI Sequence Detail	13276	C57BL/6J	± kb
transcript	NM_133349	RefSeq \| MGI Sequence Detail	3191	C57BL/6
polypeptide	Q9JII7	UniProt \| EBI \| MGI Sequence Detail	171	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017621 AN1-type zinc finger protein 2A

(term hierarchy)
InterPro Domains

IPR035896 AN1-like Zinc finger

IPR000058 Zinc finger, AN1-type

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All nucleic 64

cDNA 64

Microarray probesets 6

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MGI:2141030

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Zfand2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr54169	Chr5:139470230-139470251 (-)	5 bp
Tssr54168	Chr5:139470175-139470228 (-)	44 bp
Tssr54167	Chr5:139470146-139470163 (-)	91 bp
Tssr54166	Chr5:139464733-139464739 (-)	5,510 bp
Tssr54165	Chr5:139464689-139464703 (-)	5,550 bp
Tssr54164	Chr5:139464310-139464326 (-)	5,928 bp
Tssr54163	Chr5:139464047-139464064 (-)	6,190 bp
Tssr54162	Chr5:139459013-139459024 (-)	11,227 bp
Tssr54161	Chr5:139458893-139458937 (-)	11,331 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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