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Ppp1r8
Gene Detail
Symbol

Name
ID
Ppp1r8
protein phosphatase 1, regulatory (inhibitor) subunit 8
MGI:2140494
Synonyms
6330548N22Rik, NIPP1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
65.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:132826929-132843169 bp, - strand
From VEGA annotation of GRCm38

  16241 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8555  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPP1R8
Gene Tree: Ppp1r8

Human
homologs
PPP1R8, protein phosphatase 1, regulatory subunit 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5511
neXtProt AC: NX_Q12972

Human Synonyms: ARD1, ARD-1, NIPP1, NIPP-1, PRO2047

Human Chr (Location): 1p35.3; chr1:27830741-27851672 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(31) Targeted(4)
Genomic Mutations involving Ppp1r8 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygouse for disruptions in this gene die between embryonic days 6.5 and 7.5.
 
Interactions
Ppp1r8 interacts with 152 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell proliferation, mRNA processing, ...
Component nuclear speck, nucleoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (5)    Tissues (1)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(47)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ppp1r8    NEW 
Molecular
reagents
All nucleic(48) cDNA(47) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009995 (Evidence)
Ensembl Gene Model ENSMUSG00000028882 (Evidence)
Entrez Gene 100336 (Evidence)
UniGene 105230
DFCI TC1577817
DoTS DT.528198
NIA Mouse Gene Index U025609
PDB 2JPE
Consensus CDS Project CCDS18736.1, CCDS71482.1
International Mouse Phenotyping Consortium Status Ppp1r8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009995 VEGA Gene Model | MGI Sequence Detail 16241 C57BL/6J ±  kb
transcript OTTMUST00000023232 VEGA | MGI Sequence Detail 2037 Not Applicable 
polypeptide OTTMUSP00000010611 VEGA | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000013131 nuclear inhibitor of protein phosphatase 1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:217675 Gao Z, et al., An AUTS2-Polycomb complex activates gene expression in the CNS. Nature. 2014 Dec 18;516(7531):349-54
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory